An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer
| Autor: | Yu Sun, Tao Liu, Hua-Fu Zhou, Xiao-Han Bi, Wen-Zhou Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Lung Neoplasms White People 03 medical and health sciences Asian People Risk Factors Internal medicine Genotype medicine Humans Radiology Nuclear Medicine and imaging Genetic Predisposition to Disease Lung cancer Genetic association Glutathione Transferase Polymorphism Genetic business.industry Null (mathematics) General Medicine Odds ratio medicine.disease Prognosis Lung cancer susceptibility 030104 developmental biology Meta-analysis Gene polymorphism business |
| Zdroj: | Journal of cancer research and therapeutics. 16(4) |
| ISSN: | 1998-4138 |
| Popis: | There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study was conducted to update it.The association studies were identified from PubMed and Cochrane Library on March 1, 2016.Sixty-three reports were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 21,220 patients with lung cancer and 21,496 controls. There was a marked association between GSTT1 null genotype and lung cancer risk in overall populations and in Asians (overall populations: Odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.07-1.28, P = 0.006; Asians: OR = 1.41, 95% CI: 1.23-1.62, P0.00001). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians, Brazilian population, and Africans.GSTT1 null genotype is associated with the lung cancer risk in overall populations and in Asians. |
| Databáze: | OpenAIRE |
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