Endovascular Stem Cell Therapy Promotes Neuronal Remodeling to Enhance Post Stroke Recovery by Alleviating Endoplasmic Reticulum Stress Modulated by BDNF Signaling

Autor: Harpreet Kaur, Deepaneeta Sarmah, Aishika Datta, Anupom Borah, Dileep R Yavagal, Pallab Bhattacharya
Rok vydání: 2022
Předmět:
Zdroj: Stem Cell Reviews and Reports. 19:264-274
ISSN: 2629-3277
2629-3269
DOI: 10.1007/s12015-022-10461-6
Popis: The impact of increased BDNF expression in brain by endovascular delivered mesenchymal stem cells (MSCs) post stroke towards modulating endoplasmic reticulum (ER) stress mediated neuronal remodeling has not been directly studied. Therefore, the present study investigates ER stress mediated neuronal remodeling following IA MSCs infusion in rodent model of ischemic stroke.Ovariectomized Sprague Dawley rats were subjected to MCAO followed by 1 × 10Post-stroke IA MSCs administration significantly increased BDNF expression and decreased ER stress markers expression at day 1 post-stroke. A gradual rise in the expression of growth associate protein-43 (GAP 43) and spinophilin were observed at 7, 14- and 28-days post-stroke indicating an increase in neuronal remodeling towards functional restoration.The results suggest that IA MSCs post-stroke can modulate neuronal remodeling by BDNF-mediated reduction in ER stress that contribute towards functional recovery.
Databáze: OpenAIRE
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