Effects of pollutants and microplastics ingestion on oxidative stress and monoaminergic activity of seabream brains
| Autor: | Antoni Sureda, Antònia Solomando, David Moranta, Manuel Jimenez-García, Pablo Arechavala-Lopez, Esther Hoyo-Alvarez, Salud Deudero, Carmen Alomar |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España) |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Microplastics Health Toxicology and Mutagenesis Neurophysiology Aquatic Science medicine.disease_cause Serotonergic Biochemistry Monoaminergic neurotransmitters Eating Sparus aurata Internal medicine Detoxification Monoaminergic medicine Ingestion Animals Biogenic Monoamines Ecosystem Pollutant Neurotransmitter Agents Chemistry Dopaminergic Brain Sea Bream Oxidative Stress Endocrinology Oxidative stress Water Pollutants Chemical |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1879-1514 |
| Popis: | Nowadays, microplastics (MPs) and adsorbed pollutants are considered a global thread to marine ecosystems. This study describes the effects of pollutants and MPs ingestion on fish brains through the assessment of oxidative stress biomarkers and monoaminergic neurotransmitters using gilthead seabream (Sparus aurata) as fish model. Juveniles were experimentally exposed to three different dietary treatments for 90 days: Control treatment (C) consisted of standard feed; Virgin treatment (V) contained feed enriched with 10% of MPs; and Exposed treatment (E) consisted of feed with 10% of MPs that were exposed to seawater in an anthropogenically impacted area for 2 months in order to enrich the plastic with the pollutants within the water column. Sampling was made at the start of the experiment (T0), at the end of the dietary treatments (T90) and after a posterior detoxification period of 30 days (T120). Results evidenced that a MPs and pollutants enriched diet increases the activity of some of the oxidative stress biomarkers (e.g. CAT and GST), and it was shown for the first time alterations on dopaminergic and serotonergic system activity on seabream brains, indicating potential neurofunctional effects associated to MPs and pollutants ingestion. In addition, results showed a tendency to recover enzymatic and brain monoaminergic neurotransmitter levels after a 30-day detoxification period. In conclusion, MPs and pollutants exposure for 90 days induced oxidative stress and changes on monoaminergic activity in the brain of S. aurata. Funding was provided by the research project “Plásticos derivados de la acuicultura: impactos y efectos en las redes tróficas marinas” (ACUIPLASTIC), with reference number CTM2017-88332-R and funded by the Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016, from the Spanish Government. LIMIA aquaculture station provided the installations and collaborated in the ACUIPLASTIC project. E. Álvarez, B. Ríos, M. Compa and J.M. Valencia provided laboratory and sampling support. A. Solomando was supported by an FPU Fellowship from the Ministry of Science, Innovation and Universities from the Spanish Government (FPU18/04689). A. Sureda was granted by the Programme of Promotion of Biomedical Research and Health Sciences, Instituto de Salud Carlos III [CIBEROBN CB12/03/30038]. |
| Databáze: | OpenAIRE |
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