Family history of psoriasis, psychological stressors, and tobacco use are associated with the development of tumor necrosis factor-α inhibitor-induced psoriasis: A case-control study
| Autor: | M. Elaine Husni, Jeffery Z. Hu, Sean E. Mazloom, Anthony P. Fernandez, Gowri Kabbur, Jason Ya, Urmi Khanna, Amy S. Nowacki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Dermatology Disease Inflammatory bowel disease 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors Risk Factors Internal medicine Psoriasis Tobacco Smoking Medicine Humans Family history Age of Onset Medical History Taking business.industry Tumor Necrosis Factor-alpha Medical record Incidence Case-control study Paradoxical reaction Odds ratio Middle Aged medicine.disease 030220 oncology & carcinogenesis Antirheumatic Agents Case-Control Studies Disease Susceptibility business Stress Psychological |
| Zdroj: | Journal of the American Academy of Dermatology. 83(6) |
| ISSN: | 1097-6787 |
| Popis: | Background Tumor necrosis factor-α inhibitor–induced psoriasis (TNFI psoriasis) is a paradoxical reaction characterized by development of a psoriasiform rash that mimics psoriasis vulgaris. Temporal onset variability and low incidence rates suggest that underlying risk factors or outside triggers have a role in TNFI psoriasis initiation. Objectives We aimed to identify underlying risk factors and outside triggers associated with TNFI psoriasis onset. Methods This case-control study included 97 patients at a tertiary care center between 2003 and 2013 who developed TNFI psoriasis. Ninety-seven control patients were matched to age, sex, disease, TNF-α inhibitor, and length of time on treatment before TNFI psoriasis onset. Patient medical records were reviewed ≥6 months immediately preceding TNFI psoriasis onset (similar equivalent time point for matched controls) for information about potential risk factors and outside factors categorized as: (1) serologic abnormalities, (2) acute events, and (3) social factors. Results Compared with those of matched controls, odds ratios (ORs) were significantly higher in the TNFI psoriasis group for psoriasis family history (OR, 16.0) and acute psychological stressors (OR, 3.14) and marginally associated with tobacco use (OR, 1.76). Conclusions Our results suggest that psoriasis family history, psychological stressors, and tobacco use might be risk factors for developing TNFI psoriasis. Performing detailed patient histories when considering TNFI therapy may be useful in identifying patients at risk for TNFI-psoriasis. |
| Databáze: | OpenAIRE |
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