Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation
| Autor: | Thomas Hummel, U. Warskulat, Ovidiu Coste, Irmgard Tegeder, Dieter Häussinger, Jörn Lötsch, G. Geisslinger |
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| Rok vydání: | 2014 |
| Předmět: |
Nociception
Pain Threshold medicine.medical_specialty Taurine Time Factors Sensory system Stimulation Mice chemistry.chemical_compound Formaldehyde Internal medicine Hereditary sensory and autonomic neuropathy medicine Animals Pain Measurement Mice Knockout Analysis of Variance Membrane Glycoproteins Chemistry General Neuroscience Membrane Transport Proteins Transporter Carbon Dioxide medicine.disease Stimulation Chemical Mice Inbred C57BL Endocrinology medicine.anatomical_structure Hyperalgesia Peripheral nervous system Anesthesia Licking |
| Zdroj: | Neuroscience. 259:63-70 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2013.11.037 |
| Popis: | The amino acid taurine is required for development and functioning of the central and peripheral nervous system where it exerts osmoregulatory, neuromodulatory and anti-apoptotic actions. It is subject to cellular import by the taurine transporter slc6a6. Absence of the transporter and consequently, absence of taurine leads to several neurologic deficits and sensory losses. In a slc6a6 knock-out mouse model, consequences of congenital taurine deficiency were assessed in nociceptive sensory processes. The formalin assay, hot plate assay, and summated generator potentials in response to local nociceptive stimulation with gaseous CO2 were applied. Reduced responsiveness of slc6a6(-/-) mice to nociceptive stimulation was observed in particular to chemical nociceptive stimuli. Scl6a6 knock-out mice spent significantly less time licking the formalin injected paw and displayed smaller amplitudes of the nociceptive nasal mucosa potentials than wild-type mice (p=0.002 and 0.01 respectively). In contrast, withdrawal latencies on a hot plate did not significantly differ, suggesting that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. As hereditary absence of taurine affects biological processes of anatomical structure development, the altered nociceptive responses likely reflect consequences of compromised peripheral nervous system development. |
| Databáze: | OpenAIRE |
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