Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood pressure in a large, homogeneous study population
| Autor: | M. Albrecht, Rainer Hoffmann, J. Metrikat, Jan R. Ortlepp, K Zerres, P Maya-Pelzer, Vera Mevissen, Peter Hanrath, Fabian Schmitz |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Systole Rest Prohormone Angiotensinogen Blood Pressure Biology White People Diastole Heart Rate Polymorphism (computer science) Germany Internal medicine parasitic diseases Renin–angiotensin system Internal Medicine medicine Humans Gene Genetics Polymorphism Genetic urogenital system Blood pressure Endocrinology Homogeneous Hypertension Exercise Test Population study Gene polymorphism hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Human Hypertension. 17:555-559 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1001587 |
| Popis: | The aim of this study was to assess the association of the angiotensinogen M235T polymorphism with arterial blood pressure (BP) at rest and under physical stress in a homogeneous large-scale study population. In all, 1903 men who passed routine medical examination for military flying duty were recruited. BP and heart rate were measured at rest, during, and after bicycle ergometry. Genotyping for the AGT M235T polymorphism was carried out by PCR and RFLP technique. The AGT T235 allele was associated with a significantly higher diastolic BP (n=1903; MM 81+/-8, MT 83+/-7, TT 83+/-8; P=0.003). Pulse pressure (PP) at rest differed significantly between AGT genotypes (n=1903; MM 51+/-10 mmHg, MT 49+/-10 mmHg, TT 49+/-10 mmHg; P=0.001). During physical activity, BP values showed no significant difference between genotypes. In healthy young men, the AGT T235 allele is significantly associated with elevated diastolic BP but also reduced PP at rest. During physical activity, the AGT polymorphism had no impact on blood pressure, indicating the existence of other counteracting mechanisms, which might balance the influence of this gene. |
| Databáze: | OpenAIRE |
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