The kinetics of acetylcholine turnover in a resting cholinergic nerve terminal and the magnitude of the cytoplasmic compartment
| Autor: | I. S. Roed, M. Weiler, Victor P. Whittaker |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Cytoplasm Kinetics Torpedo Biochemistry law.invention Choline Cellular and Molecular Neuroscience chemistry.chemical_compound law Internal medicine medicine Animals Receptors Cholinergic Motor Neurons Electric Organ Chemistry Compartment (chemistry) Acetylcholine Cell Compartmentation Cytosol Endocrinology Biophysics Cholinergic Female medicine.drug |
| Zdroj: | Journal of neurochemistry. 38(5) |
| ISSN: | 0022-3042 |
| Popis: | The magnitude of the cytosolic pool of acetylcholine in the cholinergic electromotor nerve terminals of Torpedo marmorata has been calculated to be 22 +/- 3% of the total by comparing the isotopic ratio of acetylcholine with that of choline when slices of electric organ were incubated with 10 microM deuterated choline. The calculation is based on a two-compartment model that assumes the presence, in unstimulated tissue, of a vesicular pool of acetylcholine that does not exchange, under resting conditions, with a second cytosolic pool; the latter, by contrast, is subject to 'futile recycling' and comes into isotopic equilibrium with the tissue choline pool. |
| Databáze: | OpenAIRE |
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