Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium
| Autor: | Adriana I. Woods, Susana S. Meschengieser, Roberto Votta, Maria J. Salviú, María V Nadal, Carlos Marchese, Patricia Casais, Maria A. Lazzari, Analía Sánchez-Luceros |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Gestational Age Normal pregnancy Von Willebrand factor Pregnancy hemic and lymphatic diseases Internal medicine von Willebrand Factor Humans Medicine Prospective Studies reproductive and urinary physiology Normal range Factor VIII biology business.industry Postpartum Period Von Willebrand factor ristocetin cofactor Hematology General Medicine medicine.disease Von Willebrand factor Antigen Parity Cross-Sectional Studies Endocrinology Hemostasis Blood Group Antigens biology.protein Gestation Female business |
| Zdroj: | Blood Coagulation & Fibrinolysis. 14:647-651 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-200310000-00005 |
| Popis: | Gestation is a challenge to haemostasis and it is associated with significant haemostatic changes. Several studies have evaluated von Willebrand factor in normal pregnancy, but none considered the personal history of bleeding. We studied a group of healthy non-bleeding women (184 pregnant, 64 puerperium, 37 non-pregnant) to evaluate normal ranges and their relationship to blood group and parity. The von Willebrand factor increased markedly from non-pregnant values up to the end of early puerperium (P < 0.0001), while factor VIII only showed a slight increase. Factor VIII and von Willebrand factor activity remained within the normal range for non-pregnant women. The return to non-pregnant factor levels occurred in late puerperium, later than previously reported. Only factor VIII was significantly lower in the O blood group (P = 0.035). As regards parity, there were no differences in factor VIII, von Willebrand factor antigen and von Willebrand factor ristocetin cofactor between primigravidae and multigravidae for any period studied (P = 0.888, 0.999, and 0.237, respectively). Our results provide reference ranges that may help to design a study in von Willebrand factor disease in pregnancy. |
| Databáze: | OpenAIRE |
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