Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia
| Autor: | Barbara J. Nicklas, Timothy S. Pardee, Bayard L. Powell, Leslie R. Ellis, Jeff D. Williamson, Kah Poh Loh, Stephen B. Kritchevsky, Neha G. Goyal, Janet A. Tooze, Heidi D. Klepin |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Inflammation Article 03 medical and health sciences 0302 clinical medicine Internal medicine Activities of Daily Living Humans Medicine 030212 general & internal medicine Geriatric Assessment Aged business.industry Induction chemotherapy Myeloid leukemia Geriatric assessment Inflammatory biomarkers Leukemia Myeloid Acute C-Reactive Protein Treatment Outcome 030220 oncology & carcinogenesis Biomarker (medicine) Female Observational study Tumor necrosis factor alpha Geriatrics and Gerontology medicine.symptom business Biomarkers |
| Zdroj: | J Geriatr Oncol |
| ISSN: | 1879-4068 |
| Popis: | OBJECTIVES: To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes. METHODS: This was a single institution ancillary study to a prospective observational study (N=20 consecutive adults aged ≥60 with newly diagnosed AML who received induction chemotherapy). Biomarkers (Interleukin-6 [IL-6], IL-6 soluble receptor [IL-6 sR], tumor necrosis factor alpha [TNFα], TNFα soluble receptor 1 [TNFα sR1], interleukin- 3 [IL-3], C-reactive protein [CRP]) were collected at start of induction, weekly for three weeks, and post-induction and were compared over time using paired t-tests. GA was administered at baseline and post-induction, and correlated with biomarker levels using Spearman correlations. Survival was estimated using Kaplan-Meier and compared by categorized biomarker level using Wilcoxon tests. RESULTS: Biomarker levels were stable during induction, except for CRP and IL-6 sR. Declines in objectively measured physical function [Short Physical Performance Battery (SPPB); r=0.71, p |
| Databáze: | OpenAIRE |
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