Shared and unique neural mechanisms underlying pediatric trichotillomania and obsessive compulsive disorder
| Autor: | Susanna Chang, Allison Vreeland, John Piacentini, Joseph O'Neill, Joseph Jurgiel, Giulia C. Salgari, Tara S. Peris, Sandra K. Loo, Jocelyn Perez |
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| Rok vydání: | 2021 |
| Předmět: |
Obsessive-Compulsive Disorder
medicine.medical_specialty Adolescent Brain activity and meditation Audiology Electroencephalography behavioral disciplines and activities Theta power Trichotillomania 03 medical and health sciences 0302 clinical medicine Eeg data Obsessive compulsive Inhibitory control medicine Humans Child Biological Psychiatry medicine.diagnostic_test Motor Cortex 030227 psychiatry Inhibition Psychological Psychiatry and Mental health Eeg activity Psychology 030217 neurology & neurosurgery Eriksen flanker task |
| Zdroj: | Psychiatry Research. 298:113653 |
| ISSN: | 0165-1781 |
| Popis: | Background Little is known about the neural underpinnings of pediatric trichotillomania (TTM). We examined error-related negativity (ERN)-amplitude and theta-EEG power differences among youth with TTM, OCD, and healthy controls (HC). Methods Forty channel EEG was recorded from 63 pediatric participants (22 with TTM, 22 with OCD, and 19 HC) during the Eriksen Flanker Task. EEG data from inhibitory control were used to derive estimates of ERN amplitude and event-related spectral power associated with motor inhibition. Results TTM and HC were similar in brain activity patterns in frontal and central regions and TTM and OCD were similar in the parietal region. Frontal ERN-amplitude was significantly larger in OCD relative to TTM and HC, who did not differ from each other. The TTM group had higher theta power compared to OCD in frontal and central regions, and higher theta than both comparison groups in right motor cortex and superior parietal regions. Within TTM, flanker task performance was correlated with EEG activity in frontal, central, and motor cortices whereas global functioning and impairment were associated with EEG power in bilateral motor and parietal cortices. Conclusions Findings are discussed in terms of shared and unique neural mechanisms in TTM and OCD and treatment implications. |
| Databáze: | OpenAIRE |
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