Vichy Thermal Spring Water (VTSW), a cosmetic ingredient of potential interest in the frame of skin ageing exposome: anin vitrostudy
| Autor: | G. Sore, Philippe Bastien, M. Liboutet, Charlotte Tacheau, D. Fagot, F. Weisgerber, M. P. Verdier, B.A. Bernard |
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| Rok vydání: | 2018 |
| Předmět: |
Keratinocytes
0301 basic medicine Aging Skin ageing Exposome DNA Repair DNA repair Pharmaceutical Science Cosmetics Dermatology In Vitro Techniques Antioxidants Transcriptome 03 medical and health sciences Ingredient Colloid and Surface Chemistry Drug Discovery medicine Homeostasis Humans In vitro study Cell Proliferation integumentary system Chemistry Water Cell Differentiation Skin Aging Cell biology Oxidative Stress Cosmetic ingredient 030104 developmental biology medicine.anatomical_structure Microscopy Fluorescence Chemistry (miscellaneous) Keratinocyte DNA Damage |
| Zdroj: | International Journal of Cosmetic Science. 40:377-387 |
| ISSN: | 0142-5463 |
| Popis: | OBJECTIVE To study the effects of the very high minerality Vichy Thermal Spring Water (VTSW) on human keratinocytes grown in vitro. METHODS The effect of VTSW was monitored by full genome transcriptomic technology and immunofluorescence microscopy. RESULTS In the presence of 50% VTSW, the expression of a number of skin homoeostasis-related genes is increased, specifically with respect to dermal-epidermal junction, epidermal cohesion and communication, keratinocyte proliferation-differentiation balance, antioxidant mechanisms and DNA repair. CONCLUSION This work suggests that VTSW could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome. |
| Databáze: | OpenAIRE |
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