Effects of Intermittent Treatment with Topical Corticosteroids and Calcineurin Inhibitors on Epidermal and Dermal Thickness Using Optical Coherence Tomography and Ultrasound
| Autor: | R. Aschoff, Awena Lang, Edmund Koch |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
integumentary system medicine.diagnostic_test Physiology business.industry Administration Topical Calcineurin Inhibitors Ultrasound Dermatology General Medicine Dermatitis Atopic Calcineurin Treatment Outcome Optical coherence tomography medicine Humans Dermatologic Agents business Glucocorticoids Tomography Optical Coherence Research Article Biomedical engineering |
| Zdroj: | Skin Pharmacol Physiol |
| ISSN: | 1660-5535 1660-5527 |
| DOI: | 10.1159/000518214 |
| Popis: | Introduction: Proactive therapy with topical corticosteroids (TCSs) is the standard treatment for chronic inflammatory diseases such as atopic dermatitis; however, skin atrophy as TCS side effect remains a concern. Methods: This 16-week, evaluator-blinded, within-patient placebo-controlled, randomized study enrolled volunteers with healthy skin conditions. For 12 weeks, their volar forearm and the back of their hand were applied with hydrocortisone acetate 1% cream (HC), methylprednisolone aceponate 0.1% cream (MPA), betamethasone valerate 0.1% cream (BMV), or an active agent-free base cream (Dermatop® Basiscreme) once daily twice weekly, and pimecrolimus 1% cream (PIM) twice daily twice weekly. Epidermal and dermal thickness was measured by optical coherence tomography and high-frequency ultrasound, respectively. Furthermore, skin atrophy and telangiectasia were determined by contact dermatoscopic photography (Dermaphot®). Results: After 8 and 12 weeks, only BMV led to significant epidermal thinning on both sites. Four weeks after the end of treatment, epidermal thickness returned to baseline. No dermal thinning, atrophy, or telangiectasia was observed. Conclusions: MPA, HC, and PIM may be more suitable for repeated and prolonged treatment, especially in chronic diseases. |
| Databáze: | OpenAIRE |
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