Magnetic Starch Microspheres, Efficacy and Elimination A New Organ-Specific Contrast Agent for Magnetic Resonance Imaging
| Autor: | Peter Leander, J Klaveness, Anne Kjersti Fahlvik, Eckart Holtz, Ulf Schroder |
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| Rok vydání: | 1990 |
| Předmět: |
Male
In vivo magnetic resonance spectroscopy Magnetic Resonance Spectroscopy Contrast effect Iron oxide Contrast Media Spleen Ferric Compounds Mice chemistry.chemical_compound Nuclear magnetic resonance medicine Animals Radiology Nuclear Medicine and imaging ED50 Mice Inbred BALB C Aqueous solution Dose-Response Relationship Drug medicine.diagnostic_test Chemistry business.industry Starch Magnetic resonance imaging General Medicine Magnetic Resonance Imaging Microspheres Acute toxicity Solutions medicine.anatomical_structure Liver Female Nuclear medicine business |
| Zdroj: | Investigative Radiology. 25:113-120 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-199002000-00003 |
| Popis: | A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization of the substance. MSM doses in a range of 0.3-1.5 mg Fe/kg caused a 50% alteration in sensitive contrast parameters (ED50 doses) of liver and spleen. The contrast effect of MSM in liver and spleen was halved within 2 to 5 days. The approximated lethal MSM dose in mice was 150-200 mg Fe/kg. MSM is a tissue-specific MR contrast substance with high efficacy, rapid bioelimination, and low acute toxicity. |
| Databáze: | OpenAIRE |
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