Early assessment of transplanted liver function: Lignocaine clearance test (MEGX)
| Autor: | K. Boudjema, G. Freys, G. Hamel, J.C. Otteni, L. Pain, T. Pottecher, B. Calon |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Lidocaine Bilirubin medicine.medical_treatment Revascularization Gastroenterology chemistry.chemical_compound Double-Blind Method Liver Function Tests Internal medicine Humans Medicine Anesthetics Local Biotransformation Prothrombin time medicine.diagnostic_test biology business.industry Factor V Middle Aged Enzymes Liver Transplantation Surgery Transplantation Treatment Outcome Anesthesiology and Pain Medicine chemistry Prothrombin Time biology.protein Liver function business Liver function tests Half-Life medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 14:397-405 |
| ISSN: | 0265-0215 |
| Popis: | The purpose of this study was to assess the value of lignocaine biotransformation into monoethylglycinexylidide (MEGX) and conventional liver function tests in the early post-operative period as an indicator of graft function and as a diagnostic tool for complications after hepatic transplantation. Monoethylglycinexylidide formation, plasma bilirubin, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), factor V index (FVI) and prothrombin time index (PTI) were measured in 71 patients undergoing 80 liver transplantations respectively at 12 (T1), 24 (T2), 48 (T3) and 72 h (T4) after liver graft revascularization. Patients were divided into two group according to the post-operative outcome. Patients with favourable outcome (n = 59) had significantly higher monoethylglycinexylidide synthesis, higher factor V index and prothrombin time index plasma concentrations, lower bilirubin, ASAT and ALAT plasma concentration (P < 0.0001 at T2 and T3) than those with complicated time course (n = 21). Monoethylglycinexylidide synthesis was the best discriminant of a favourable outcome, whereas bilirubin and ALAT concentrations were associated with complications (bilirubin for primary non function [PNF], ALAT for acute rejection). Thus, the combination of parameters at T2 was a very efficient predictor of primary non function, acute rejection and an uncomplicated time course. |
| Databáze: | OpenAIRE |
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