Brain insulin sensitivity is linked to adiposity and body fat distribution
| Autor: | Robert Wagner, Martin Heni, Valenta, Juergen Machann, Hubert Preissl, Otto Tschritter, Stephanie Kullmann, Andreas Fritsche, HU Häring |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Science medicine.medical_treatment General Physics and Astronomy 030209 endocrinology & metabolism Intra-Abdominal Fat General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Insulin resistance Weight loss Internal medicine Diabetes mellitus medicine Humans Obesity lcsh:Science Letter to the Editor Adiposity Body fat distribution Multidisciplinary business.industry Insulin Brain Insulin sensitivity Cancer General Chemistry Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Hypothalamus Body Composition Female lcsh:Q Insulin Resistance medicine.symptom business |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020) Nat. Commun. 11:1841 (2020) European Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-15686-y |
| Popis: | Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass during a nine year follow-up. Cross-sectionally, strong insulin responsiveness of the hypothalamus associates with less visceral fat, while subcutaneous fat is unrelated. Our results demonstrate that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution. Since visceral fat is strongly linked to diabetes, cardiovascular risk and cancer, these findings have implications beyond metabolic diseases and indicate the necessity of strategies to resolve brain insulin resistance. |
| Databáze: | OpenAIRE |
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