Oxidized low density lipoprotein (Ox-LDL) as a marker of atherosclerosis in hemodialysis (HD) patients
| Autor: | Shintaro Iwasaki, H Suzuki, E Oshima, K Takahashi, T Takenaka, T Kobayashi |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Arteriosclerosis medicine.medical_treatment Oxidized low density lipoprotein Alpha (ethology) medicine.disease_cause chemistry.chemical_compound Renal Dialysis Internal medicine medicine Humans Vitamin E Prospective Studies Prospective cohort study Hemodialysis hd Vascular disease business.industry General Medicine Middle Aged medicine.disease Lipoproteins LDL Endocrinology chemistry Nephrology Linear Models Female Hemodialysis business Biomarkers Oxidative stress |
| Zdroj: | Clinical Nephrology. 58:33-37 |
| ISSN: | 0301-0430 |
| DOI: | 10.5414/cnp58033 |
| Popis: | AIM To characterize the relationship between oxidative stress and atherosclerosis in HD patients. METHODS Seventy-five HD patients were entered into the study. Ox-LDL was measured as a probe for peroxidation and compared to clinical atherosclerotic parameters. Prospective studies were also performed to assess the effects of vitamin E-bonded membrane on oxidative stress. RESULTS Elderly patients tended to show elevated Ox-LDL (alpha = 0.060+/-0.021 ng/microg LDL protein/year, r = 0.35, p < 0.05). Levels of Ox-LDL in the patients with positive history for atherosclerotic diseases (3.1+/-0.4 ng/microg LDL protein, n = 36) were higher than those with a negative history (1.6+/-0.2, n = 39, p < 0.01). Further-more, ankle/brachial pressure index was negatively correlated to Ox-LDL (alpha = -0.052+/-0.012/ng/microg LDL protein, r = 0.42, p < 0.01). Application of vitamin E-bonded membrane for 10 months (-38+/-11%, n = 14, p < 0.05), but not synthetic membrane, ameliorated Ox-LDL. CONCLUSIONS Our results indicate that Ox-LDL is elevated in aged HD patients. In addition, the present data provide evidence that vitamin E-bonded dialyzers attenuate oxidative stress. Finally, our findings suggest that Ox-LDL correlates to the magnitude of peripheral arterial diseases in HD patients. |
| Databáze: | OpenAIRE |
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