Effectiveness of quadrivalent influenza vaccine in pregnant women and infants, 2018–2019
Autor: | Pelopidas Koutroumanis, Maria Theodoridou, Dimitrios Loutradis, Marianna Theodora, George Daskalakis, Athanassios Kossyvakis, Sofoklis Stavrou, George Asimakopoulos, Andreas Mentis, Alexandros Rodolakis, Panos Katerelos, Michael Sindos, Petros Drakakis, Stavroula Gavrili, Evangelos Kostis, Helena C. Maltezou |
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Rok vydání: | 2020 |
Předmět: |
Quadrivalent Inactivated Influenza Vaccine
Pediatrics medicine.medical_specialty medicine.drug_class 030231 tropical medicine Antibiotics Lower risk 03 medical and health sciences 0302 clinical medicine Pregnancy Influenza Human medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Medical prescription General Veterinary General Immunology and Microbiology business.industry Proportional hazards model Vaccination Public Health Environmental and Occupational Health Infant virus diseases Odds ratio Confidence interval Infectious Diseases Influenza Vaccines Molecular Medicine Female Pregnant Women business |
Zdroj: | Vaccine. 38:4625-4631 |
ISSN: | 0264-410X |
Popis: | Influenza is associated with an increased risk for serious illness, hospitalization and/or death in pregnant women and young infants. We prospectively studied the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during the 2018-2019 influenza season. A QIV was offered to pregnant women cared in a maternity hospital in Athens. Women were contacted weekly by telephone during the influenza season and PCR test was offered to women or infants who developed influenza-like illness (ILI). We studied 423 pregnant women and 446 infants. Unvaccinated pregnant women had a 7.5% probability to develop laboratory-confirmed influenza compared to 2.1% among vaccinated women (Odds ratio: 3.6; confidence intervals: 1.14-11.34, p-value = 0.029). Infants whose mothers were not vaccinated had a 7.9% probability to develop laboratory-confirmed influenza compared to 2.8% among infants of vaccinated mothers (Odds ratio = 2.849, confidence intervals: 0.892-9.102, p-value = 0.053). Cox regression analyses showed that QIV vaccination was significantly associated with a decreased probability for laboratory-confirmed influenza, ILI, healthcare seeking and hospitalization among pregnant women and a decreased probability for laboratory-confirmed influenza, healthcare seeking and prescription of antibiotics among infants. The effectiveness of QIV against laboratory-confirmed influenza was 72% among pregnant women and 64.5% among infants during the 2018-2019 influenza season. Vaccination of pregnant women with the QIV was associated with a lower risk for laboratory-confirmed influenza for them and their infants during the influenza season. Our findings strongly support the World Health Organization recommendations for vaccinating pregnant women against influenza. |
Databáze: | OpenAIRE |
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