Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents
| Autor: | Zheng Cui, Bingdi Chen, Xin Chen, Shaobin Cui, Wenjun Le, Huanhuan Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
General Chemical Engineering Gadolinium chemistry.chemical_element Nanotechnology Computed tomography 02 engineering and technology 010402 general chemistry 01 natural sciences Article gold nanocluster bovine serum albumin contrast agent magnetic resonance imaging computed tomography Nanoclusters lcsh:Chemistry chemistry.chemical_compound Dynamic light scattering Nano medicine General Materials Science Chelation medicine.diagnostic_test 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences lcsh:QD1-999 chemistry Diethylenetriamine 0210 nano-technology Nuclear chemistry |
| Zdroj: | Nanomaterials Nanomaterials; Volume 6; Issue 4; Pages: 65 Nanomaterials, Vol 6, Iss 4, p 65 (2016) |
| ISSN: | 2079-4991 |
| Popis: | Multi-modal imaging plays a key role in the earlier detection of disease. In this work, a facile bioinspired method was developed to synthesize Gd-functionalized gold nanoclusters (Gd-Au NCs). The Gd-Au NCs exhibit a uniform size, with an average size of 5.6 nm in dynamic light scattering (DLS), which is a bit bigger than gold clusters (3.74 nm, DLS), while the fluorescent properties of Gd-Au NCs are almost the same as that of Au NCs. Moreover, the Gd-Au NCs exhibit a high longitudinal relaxivity value (r1) of 22.111 s−1 per mM of Gd in phosphate-buffered saline (PBS), which is six times higher than that of commercial Magnevist (A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, Gd-DTPA, r1 = 3.56 mM−1·s−1). Besides, as evaluated by nano single photon emission computed tomography (SPECT) and computed tomography (CT) the Gd-Au NCs have a potential application as CT contrast agents because of the Au element. Finally, the Gd-Au NCs show little cytotoxicity, even when the Au concentration is up to 250 μM. Thus, the Gd-Au NCs can act as multi-modal imaging contrast agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|