Risk Assessment of Bovine Major Histocompatibility Complex Class II DRB3 Alleles for Perinatal Transmission of Bovine Leukemia Virus
| Autor: | Sohei Yasuda, Munehito Mimura, Chieh-Wen Lo, Hirotaka Sato, Rania Hamada, Lanlan Bai, Naoko Tanaka, Michihito Inokuma, Anna Yasui, Shuji Yoneyama, Liushiqi Borjigin, Shin-nosuke Takeshima, Yoko Aida, Yasuo Shinozaki, Risa Yamanaka |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) dam disease resistance 040301 veterinary sciences viruses animal diseases proviral load perinatal infection BoLA-DRB3 polymorphism Human leukocyte antigen Biology Plant disease resistance Article law.invention 0403 veterinary science 03 medical and health sciences disease suitability law Immunology and Allergy Allele Molecular Biology Gene calf General Immunology and Microbiology Bovine leukemia virus 04 agricultural and veterinary sciences biochemical phenomena metabolism and nutrition biology.organism_classification Virology Breed 030104 developmental biology Infectious Diseases Transmission (mechanics) bovine leukemia virus Herd Medicine |
| Zdroj: | Pathogens Pathogens, Vol 10, Iss 502, p 502 (2021) Volume 10 Issue 5 |
| ISSN: | 2076-0817 |
| Popis: | Perinatal transmission plays a critical role in the spread of bovine leukemia virus (BLV) infection in cattle herds. In the Holstein breed, we previously identified BLV resistant and susceptible bovine leukocyte antigen (BoLA)-DRB3 alleles, including BoLA-DRB3*009:02 and *014:01:01 with a low BLV proviral load (PVL), and *015:01 and *012:01 with a high PVL. Here, we evaluated the perinatal BLV transmission risk in dams with different BoLA-DRB3 alleles. BoLA-DRB3 alleles of 120 dam-calf pairs from five dairy farms in Japan were identified their PVL was quantified using the BLV-Coordination of Common Motifs (CoCoMo)-qPCR-2 assay. Ninety-six dams were BLV-positive, and 29 gave birth to BLV-infected calves. Perinatal transmission frequency was 19% in dams with resistant alleles suppressed to a low PVL level, and 38% and 25% in dams with susceptible and neutral alleles that maintained high PVL levels, respectively. Notably, all calves with resistant alleles were BLV free, whereas 30% of calves with susceptible genes were infected. Thus, vertical transmission risk was extremely lower for dams and calves with resistant alleles compared to those with susceptible alleles. Our results can inform the development of effective BLV eradication programs under field conditions by providing necessary data to allow for optimal selection of dams for breeding. |
| Databáze: | OpenAIRE |
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