GATA3 immunohistochemistry in urothelial carcinoma of the upper urinary tract as a urothelial marker and a prognosticator

Autor:	Satoshi Inoue, Norio Nonomura, Abdelrazak Meliti, Hiroki Ide, Taichi Mizushima, Seiji Yamaguchi, Kazutoshi Fujita, George J. Netto, Hiroshi Miyamoto, Hiroaki Fushimi
Rok vydání:	2017
Předmět:	Male 0301 basic medicine medicine.medical_specialty Pathology Time Factors Biopsy Urology Down-Regulation GATA3 Transcription Factor Kaplan-Meier Estimate Biology Disease-Free Survival Pathology and Forensic Medicine Surgical pathology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Biomarkers Tumor medicine Carcinoma Estrogen Receptor beta Humans Neoplasm Invasiveness Urothelium Lymph node Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test Hazard ratio Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Urinary Bladder Neoplasms Receptors Androgen Tissue Array Analysis Tumor progression 030220 oncology & carcinogenesis Multivariate Analysis Female Neoplasm Grading
Zdroj:	Human Pathology. 64:83-90
ISSN:	0046-8177
Popis:	Immunohistochemistry of a transcription factor, GATA3, has been widely used as a promising urothelial marker in diagnostic surgical pathology practice. However, the expression status of GATA3 in upper urinary tract urothelial carcinomas (UUTUCs) and its prognostic significance have not been fully investigated. We immunohistochemically stained for GATA3 in 99 UUTUC samples and paired nonneoplastic urothelial tissues. GATA3 was positive in 51 (51.5%; 32 [32.3%] weak, 11 [11.1%] moderate, 8 [8.1%] strong) of 99 UUTUCs, which was significantly lower than in benign urothelium (79 [96.3%] of 82; 33 [40.2%] weak, 35 [42.7%] moderate, 11 [13.4%] strong; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea2cc35e49f3b1db465f8c21a359864 https://doi.org/10.1016/j.humpath.2017.04.003 Zobrazit plný text záznamu Full Text from ScienceDirect