New hydrogen donor: a facile method for the removal of hydrogenolysable protecting groups in Peptide synthesis
| Autor: | B. Mahesh, Gowda Dc |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Peptide Biosynthesis
Hydrogen Base (chemistry) Formates Formic acid Hydrazine chemistry.chemical_element Biochemistry Catalysis chemistry.chemical_compound Catalytic transfer hydrogenation Structural Biology Peptide synthesis Organic chemistry Amino Acids chemistry.chemical_classification General Medicine Carbon Hydrazines chemistry Lead Models Chemical Peptides |
| Zdroj: | Protein and peptide letters. 9(3) |
| ISSN: | 0929-8665 |
| Popis: | Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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