White matter microstructural impairments in amyotrophic lateral sclerosis: A mean apparent propagator MRI study

Autor: Yan-Juan Lin, Jia-Hui Lin, Xu-Feng Yao, Hua-Jun Chen, Chuanyin Zhan, Li-Min Cai, Min-Xiong Zhou, Zhang-Yu Zou
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Mean apparent propagator
NG
non-Gaussianity
PDF
probability density function
NODDI
neurite orientation dispersion and density imaging
Pyramidal Tracts
Corpus callosum
Nuclear magnetic resonance
RTPP
return-to-plane probability
ISO
isotropic compartment fraction
Amyotrophic lateral sclerosis
FA
fractional anisotropy
NDI
neurite density index
CST
corticospinal tract
HCs
healthy controls
medicine.diagnostic_test
AK
axial kurtosis
White matter
Regular Article
RK
radial kurtosis
ALS
amyotrophic lateral sclerosis
Magnetic Resonance Imaging
RD
radial diffusivity
medicine.anatomical_structure
Diffusion Tensor Imaging
Neurology
RTAP
return-to-axis probability
Kurtosis
AD
axial diffusivity
ODI
orientation dispersion index
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
MAP
mean apparent propagator
Subgroup analysis
NG||
parallel NG
medicine
Humans
Radiology
Nuclear Medicine and imaging
WM
white matter
RC346-429
MD
mean diffusivity
business.industry
RTOP
return-to-origin probability
Magnetic resonance imaging
Diffusion weighted imaging
medicine.disease
Corticospinal tract
NG⊥
perpendicular NG
DKI
diffusion kurtosis imaging
MK
mean kurtosis
VBA
voxel-wise analysis
Neurology (clinical)
DTI
diffusion tensor imaging
Neurology. Diseases of the nervous system
business
MRI
magnetic resonance imaging
ALSFRS-R
revised ALS Functional Rating Scale
Diffusion MRI
Zdroj: NeuroImage: Clinical, Vol 32, Iss, Pp 102863-(2021)
NeuroImage : Clinical
ISSN: 2213-1582
Popis: Background: White matter (WM) impairment is a hallmark of amyotrophic lateral sclerosis (ALS). This study evaluated the capacity of mean apparent propagator magnetic resonance imaging (MAP-MRI) for detecting ALS-related WM alterations. Methods: Diffusion images were obtained from 52 ALS patients and 51 controls. MAP-derived indices [return-to-origin/-axis/-plane probability (RTOP/RTAP/RTPP) and non-Gaussianity (NG)/perpendicular/parallel NG (NG⊥/NG||)] were computed. Measures from diffusion tensor/kurtosis imaging (DTI/DKI) and neurite orientation dispersion and density imaging (NODDI) were also obtained. Voxel-wise analysis (VBA) was performed to determine differences in these parameters. Relationship between MAP parameters and disease severity (assessed by the revised ALS Functional Rating Scale (ALSFRS-R)) was evaluated by Pearson’s correlation analysis in a voxel-wise way. ALS patients were further divided into two subgroups: 29 with limb-only involvement and 23 with both bulbar and limb involvement. Subgroup analysis was then conducted to investigate diffusion parameter differences related to bulbar impairment. Results: The VBA (with threshold of P
Databáze: OpenAIRE
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