A double-blind, placebo-controlled randomized trial of creatine for the cancer anorexia/weight loss syndrome (N02C4): an Alliance trial
| Autor: | C. S. Adonizio, Charles L. Loprinzi, Preston D. Steen, Jeff A. Sloan, Kendrith M. Rowland, Dennis F. Moore, Anthony J. Jaslowski, Nguyet A. Le-Lindqwister, Aminah Jatoi, Pamela J. Atherton |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Anorexia Creatine Placebo Cachexia law.invention Placebos 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial Double-Blind Method law Weight loss Internal medicine Neoplasms Weight Loss Clinical endpoint Medicine Humans Aged business.industry Hematology Original Articles Middle Aged medicine.disease 030104 developmental biology Endocrinology Oncology chemistry 030220 oncology & carcinogenesis Female medicine.symptom business Weight gain |
| Popis: | Background Multiple pilot studies, including one in colorectal cancer patients, suggest that creatine, an amino acid derivative, augments muscle, improves strength, and thereby could palliate the cancer anorexia/weight loss syndrome. Patients and methods In this randomized, double-blind, placebo-controlled trial, incurable patients with this syndrome were assigned creatine (20 g/day load×5 days followed by 2 g/day orally) versus identical placebo. Patients were weighed once a week for 1 month and then monthly. Patients were also assessed over 1 month for appetite and quality of life (validated questionnaires), fist grip strength, body composition (bioelectrical impedance), and adverse events. The primary endpoint was 10% or greater weight gain from baseline during the first month. Results Within this combined cohort of 263 evaluable patients (134 received creatine and 129 placebo), only 3 gained ≥10% of their baseline weight by 1 month: two creatine-treated and the other placebo-exposed (P = 1.00). Questionnaire data on appetite, quality of life, and activities of daily living showed no statistically significant differences between groups. Similarly, no statistically significant differences between groups were observed for fist-grip strength or body composition. Rates and severity of adverse events were comparable between groups. Finally, a median survival of 230 and 239 days were observed in the creatine and placebo groups, respectively (P = 0.70). Conclusion Creatine, as prescribed in this trial, had no effect on the cancer anorexia/weight loss syndrome. |
| Databáze: | OpenAIRE |
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