Genetic studies of body mass index yield new insights for obesity biology
| Autor: | Locke, Adam E, Kahali, Bratati, Croteau-Chonka, Damien C, Doney, Alex S F, He, Bing, Heikkilä, Outi, Hietala, Kustaa, Kytö, Janne, Lahermo, Päivi, Lehto, Markku, Österholm, Anne-May, Parkkonen, Maija, Pitkäniemi, Janne, Rosengård-Bärlund, Milla, Eklund, Niina, Saraheimo, Markku, Sarti, Cinzia, Söderlund, Jenny, Soro-Paavonen, Aino, Syreeni, Anna, Thorn, Lena M, Tikkanen, Heikki, Tolonen, Nina, Tryggvason, Karl, Tuomilehto, Jaakko, Estrada, Karol, Wadén, Johan, Gill, Geoffrey V, Prior, Sarah, Guiducci, Candace, Mirel, Daniel B, Taylor, Andrew, Hosseini, Mohsen, Parving, Hans-Henrik, Rossing, Peter, Tarnow, Lise, Eury, Elodie, Ladenvall, Claes, Alhenc-Gelas, François, Lefebvre, Pierre, Rigalleau, Vincent, Roussel, Ronan, Tregouet, David-Alexandre, Maestroni, Anna, Maestroni, Silvia, Falhammar, Henrik, Gu, Tianwei, Folkersen, Lasse, Möllsten, Anna, Cimponeriu, Dan, Mihai, Ioana, Mota, Maria, Mota, Eugen, Serafinceanu, Cristian, Stavarachi, Monica, Hanson, Robert L, Nelson, Robert G, Kretzler, Matthias, Fraser, Ross M, Colhoun, Helen M, Panduru, Nicolae Mircea, Gu, Harvest F, Brismar, Kerstin, Zerbini, Gianpaolo, Hadjadj, Samy, Marre, Michel, Groop, Leif, Lajer, Maria, Bull, Shelley B, Garcia, Melissa E, Waggott, Daryl, Paterson, Andrew D, Savage, David A, Bain, Stephen C, Martin, Finian, Hirschhorn, Joel N, Godson, Catherine, Florez, Jose C, Groop, Per-Henrik, Maxwell, Alexander P, Geller, Frank, Willer, Cristen J, Schmidt, Ellen M, Sengupta, Sebanti, Peloso, Gina M, Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L, Mora, Samia, Giedraitis, Vilmantas, Beckmann, Jacques S, Bragg-Gresham, Jennifer L, Chang, Hsing-Y, Demirkan, Ayşe, Den Hertog, Heleen M, Do, Ron, Donnelly, Louise A, Ehret, Georg B, Esko, Tõnu, Feitosa, Mary F, Gigante, Bruna, Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Freitag, Daniel F, Gurdasani, Deepti, Heikkilä, Kauko, Hyppönen, Elina, Isaacs, Aaron, Jackson, Anne U, Esko, Tonu, Go, Alan S, Johansson, Åsa, Johnson, Toby, Kaakinen, Marika, Kettunen, Johannes, Kleber, Marcus E, Li, Xiaohui, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Magnusson, Patrik K E, Mangino, Massimo, Golay, Alain, Mihailov, Evelin, Montasser, May E, Müller-Nurasyid, Martina, Nolte, Ilja M, O'Connell, Jeffrey R, Palmer, Cameron D, Perola, Markus, Petersen, Ann-Kristin, Sanna, Serena, Saxena, Richa, Goodall, Alison H, Service, Susan K, Shah, Sonia, Shungin, Dmitry, Sidore, Carlo, Song, Ci, Strawbridge, Rona J, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Thorleifsson, Gudmar, Gordon, Scott D, Van den Herik, Evita G, Voight, Benjamin F, Volcik, Kelly A, Waite, Lindsay L, Wong, Andrew, Wu, Ying, Zhang, Weihua, Absher, Devin, Asiki, Gershim, Barroso, Inês, Gorski, Mathias, Been, Latonya F, Bolton, Jennifer L, Bonnycastle, Lori L, Brambilla, Paolo, Burnett, Mary S, Cesana, Giancarlo, Dimitriou, Maria, Doring, Angela, Elliott, Paul, Grabe, Hans-Jörgen, Epstein, Stephen E, Eyjolfsson, Gudmundur Ingi, Goodarzi, Mark O, Grallert, Harald, Gravito, Martha L, Groves, Christopher J, Hallmans, Göran, Hartikainen, Anna-Liisa, Hayward, Caroline, Hernandez, Dena, Hicks, Andrew A, Holm, Hilma, Hung, Yi-Jen, Illig, Thomas, Jones, Michelle R, Kaleebu, Pontiano, Kastelein, John J P, Khaw, Kay-Tee, Kim, Eric, Grammer, Tanja B, Klopp, Norman, Komulainen, Pirjo, Kumari, Meena, Langenberg, Claudia, Lehtimaki, Terho, Lin, Shih-Yi, Lindstrom, Jaana, Loos, Ruth J F, Mach, François, McArdle, Wendy L, Gräßler, Jürgen, Meisinger, Christa, Mitchell, Braxton D, Muller, Gabrielle, Nagaraja, Ramaiah, Narisu, Narisu, Nieminen, Tuomo V M, Nsubuga, Rebecca N, Olafsson, Isleifur, Ong, Ken K, Palotie, Aarno, Grönberg, Henrik, Papamarkou, Theodore, Pomilla, Cristina, Pouta, Anneli, Rader, Daniel J, Reilly, Muredach P, Ridker, Paul M, Rivadeneira, Fernando, Rudan, Igor, Ruokonen, Aimo, Samani, Nilesh, Fall, Tove, Scharnagl, Hubert, Seeley, Janet, Silander, Kaisa, Stančáková, Alena, Stirrups, Kathleen, Swift, Amy J, Tiret, Laurence, Uitterlinden, Andre G, van Pelt, L Joost, Vedantam, Sailaja, Gusto, Gaëlle, Wainwright, Nicholas, Wijmenga, Cisca, Wild, Sarah H, Willemsen, Gonneke, Wilsgaard, Tom, Wilson, James F, Young, Elizabeth H, Zhao, Jing Hua, Adair, Linda S, Arveiler, Dominique, Haessler, Jeffrey, Assimes, Themistocles L, Bandinelli, Stefania, Bennett, Franklyn, Bochud, Murielle, Boehm, Bernhard O, Boomsma, Dorret I, Borecki, Ingrid B, Bornstein, Stefan R, Bovet, Pascal, Burnier, Michel, Hall, Per, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C, Chen, Yii-Der Ida, Collins, Francis S, Cooper, Richard S, Danesh, John, Dedoussis, George, de Faire, Ulf, Feranil, Alan B, Haller, Toomas, Ferrieres, Jean, Ferrucci, Luigi, Freimer, Nelson B, Gieger, Christian, Groop, Leif C, Gudnason, Vilmundur, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Hingorani, Aroon, Hallmans, Goran, Hofman, Albert, Hovingh, G Kees, Hsiung, Chao Agnes, Humphries, Steve E, Hunt, Steven C, Hveem, Kristian, 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Mar-Liis, Tikkanen, Emmi, Tyrer, Jonathon, van Meurs, Joyve B J, Waeber, Gerard, Takahashi, Atsushi, Young, Lauren, Zhuang, Wei Vivian, Bierut, Laura J, Boyd, Heather A, Tanaka, Toshihiro, Econs, Michael J, van 't Hooft, Ferdinand M, Vinkhuyzen, Anna A E, Westra, Harm-Jan, Consortium, ADIPOGen, Group, AGEN-BMI Working, Consortium, CARDIOGRAMplusC4D, Consortium, CKDGen, GLGC, ICBP, Fehrmann, Rudolf, Investigators, MAGIC, Consortium, MuTHER, Consortium, MIGen, Consortium, PAGE, Consortium, ReproGen, Consortium, GENIE, Consortium, International Endogene, Beilby, John, Blangero, John, Karjalainen, Juha, Crawford, Dana C, Cusi, Daniele, den Ruijter, Hester M, Erbel, Raimund, Justice, Anne E, Felix, Stephan B, Ferrannini, Ele, Ferrières, Jean, Franco, Oscar H, Gansevoort, Ron T, Gejman, Pablo V, Gottesman, Omri, Hattersley, Andrew T, Hindorff, Lucia A, Homuth, Georg, Jacobs, Kevin B, Anderson, Denise, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M, Kiemeney, Lambertus A, Knekt, Paul, Beekman, Marian, Kraja, Aldi T, Marchand, Loic Le, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C, Moll, Frans L, Ohlsson, Claes, Madden, Pamela A F, Pasterkamp, Gerard, Buyske, Steven, Qi, Lu, Raitakari, Olli T, Rankinen, Tuomo, Rao, D. C., Rice, Treva K, Rioux, John D, Ritchie, Marylyn D, Sarzynski, Mark A, Sever, Peter, Sinisalo, Juha, Deng, Guohong, Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Virtamo, Jarmo, Vohl, Marie-Claude, Pers, Tune H, Witteman, Jacqueline C, Amouyel, Philippe, Asselbergs, Folkert W, Bottinger, Erwin P, Bouchard, Claude, Cauchi, Stéphane, de Bakker, Paul I W, Haiman, Christopher A, Kaplan, Robert C, Moebus, Susanne, Pérusse, Louis, Schadt, Eric E, Slagboom, P Eline, Walker, Mark, Weir, David R, Zanen, Pieter, Fox, Caroline S, Heid, Iris M, Scherag, André, Kristiansson, Kati, Speliotes, Elizabeth K, Day, Felix R, Goldstein, Benjamin A, Cazier, Jean-Baptiste, Lotay, Vaneet, Ho, Weang K, Eriksson, Niclas, Lundmark, Per, Rafelt, Suzanne, Leach, Irene Mateo, Van Zuydam, Natalie, Medina-Gomez, Carolina, Burgdorf, Christof, Claudi-Boehm, Simone, Cox, David, El Mokhtari, NourEddine, Hager, Jörg, Hunt, Sarah E, Kang, Hyun M, Kessler, Thorsten, Knowles, Joshua W, Kolovou, Genovefa, Langford, Cordelia, Lokki, Marja-Liisa, Lundmark, Anders, Maouche, Seraya, Nikus, Kjell, Rayner, N William, Pasko, Dorota, Rosinger, Silke, Rubin, Diana, Rumpf, Moritz P, Schäfer, Arne, Sivananthan, Mohan, Stewart, Alexandre F R, Thorgeirsson, Gudmundur, Pechlivanis, Sonali, van der Schoot, C Ellen, Wagner, Peter J, Wells, George A, Wild, Philipp S, Tsun-Po, Yang, Basart, Hanneke, Powell, Corey, Peters, Marjolein J, Cupples, Adrienne L, Diemert, Patrick, Evans, Alun, Ferrario, Marco M, Gauguier, Dominique, Gudnason, Villi, Hazen, Stanley L, Jang, Yangsoo, Kee, Frank, Kim, Hyo-Soo, Kuulasmaa, Kari, Laaksonen, Reijo, Lee, Ji-Young, Ouwehand, Willem H, Parish, Sarah, Park, Jeong E, Schadt, Eric, Shah, Svati H, Wareham, Nicholas, Zimmermann, Martina E, Nieminen, Markku S, Sung, Yun Ju, Pastinen, Tomi, Zalloua, Pierre A, Blankenberg, Stefan S, O'Donnell, Christopher, Roberts, Robert, Garnaas, Maija, Böger, Carsten A, Fuchsberger, Christian, Tin, Adrienne, Taliun, Daniel, Li, Man, van der Laan, Sander W, Gao, Xiaoyi, Yang, Qiong, Hundertmark, Claudia, Foster, Meredith C, O'Seaghdha, Conall M, van Setten, Jessica, Struchalin, Maksim, Li, Guo, Gierman, Hinco J, Feitosa, Mary, Atkinson, Elizabeth J, Lohman, Kurt, Van Vliet-Ostaptchouk, Jana V, Chouraki, Vincent, Holliday, Elizabeth G, Sorice, Rossella, Kutalik, Zoltan, Wang, Zhaoming, Deshmukh, Harshal, Chu, Audrey Y, Murgia, Federico, Imboden, Medea, Kollerits, Barbara, Schmidt, Helena, Cavalieri, Margherita, Rao, Madhumathi, de Andrade, Mariza, Turner, Stephen T, Ding, Jingzhong, Freedman, Barry I, Minelli, Cosetta, Wheeler, Heather E, Zaboli, Ghazal, Ellinghaus, David, Nöthlings, Ute, Jacobs, Gunnar, Biffar, Reiner, Endlich, Karlhans, Nauck, Matthias, Stracke, Sylvia, Ärnlöv, Johan, Aulchenko, Yurii S, Hastie, Nick, Arscott, Gillian M, Helmer, Catherine, Wang, Jie Jin, Ruggiero, Daniela, Nikopensius, Tiit, Province, Michael, Ketkar, Shamika, Attwood, Antony P, Colhoun, Helen, Doney, Alex, Robino, Antonietta, Giulianini, Franco, Krämer, Bernhard K, Portas, Laura, Buckley, Brendan M, Adam, Martin, Thun, Gian-Andri, Paulweber, Bernhard, Haun, Margot, Metzger, Marie, Mitchell, Paul, Ciullo, Marina, Kim, Stuart K, Palmer, Colin, Pirastu, Mario, Probst-Hensch, Nicole M, Kronenberg, Florian, Bas, Isabelita N, Schmidt, Reinhold, Borecki, Ingrid, Curhan, Gary C, Bellis, Claire, Franke, Andre, Ridker, Paul, Bennett, Amanda J, Goessling, Wolfram, Kao, W H Linda, Berne, Christian, de Boer, Ian H, Peralta, Carmen A, Blagieva, Roza, Akylbekova, Ermeg, Kramer, Holly, Blüher, Matthias, Böhringer, Stefan, Egan, Josephine, Reilly, Muredach, Townsend, Raymond R, Lumley, Thomas, Kestenbaum, Bryan, Haritunians, Talin, Yang, Jian, Böttcher, Yvonne, Lu, Xiaoning, Leak, Tennille S, Aasarød, Knut, Skorpen, Frank, Baumert, Jens, Devuyst, Olivier, Mychaleckyj, Josyf C, Kedenko, Lyudmyla, Coassin, Stefan, Caspersen, Ida H, Curhan, Gary, Hallan, Stein, Shlipak, Michael G, Kao, W. H. L., Anderson, Carl A, Daw, E Warwick, Guo, Qun, Henders, Anjali K, Lambert, Ann, Lee, Sang Hong, Kennedy, Stephen H, Macgregor, Stuart, Missmer, Stacey A, de Craen, Anton J M, Painter, Jodie N, Roseman, Fenella, Treloar, Susan A, Wallace, Leanne, Delgado, Graciela, McKnight, Amy Jayne, Forsblom, Carol, Isakova, Tamara, McKay, Gareth J, Williams, Winfred W, Sadlier, Denise M, Mäkinen, Ville-Petteri, Swan, Elizabeth J, Palmer, Cameron, Boright, Andrew P, Ahlqvist, Emma, Deshmukh, Harshal A, Keller, Benjamin J, Huang, Huateng, Ahola, Aila, Fagerholm, Emma, Gordin, Daniel, Harjutsalo, Valma |
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| Přispěvatelé: | Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Lifestyle, Overweight and Diabetes, Epidemiology, Internal Medicine, Child and Adolescent Psychiatry / Psychology, Clinical Genetics, Obstetrics & Gynecology, Locke, Adam E, Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'An, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Leach, Irene Mateo, Medina Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Van Der Laan, Sander W., Van Setten, Jessica, Van Vliet Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthia, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Chen, Yii Der Ida, Clarke, Robert, Daw, E. Warwick, De Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmanta, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathia, Grabe, Hans Jörgen, Grallert, Harald, Grammer, Tanja B., Gräßler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Tooma, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lar, Lindström, Jaana, Lo, Ken Sin, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, Françoi, Magnusson, Patrik K. E., Mahajan, Anubha, Mcardle, Wendy L., Mclachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thoma, Shi, Jianxin, Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann Christine, Tan, Sian Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco Cereceda, Ander, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, Mccarroll, Steven A., Mcknight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, Va't Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Cupples, L. Adrienne, Cusi, Daniele, Danesh, John, De Faire, Ulf, Den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Hovingh, G. Kee, Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thoma, Jacobs, Kevin B., Jarvelin, Marjo Riitta, Jöckel, Karl Heinz, Johansen, Berit, Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charle, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., Mckenzie, Colin A., Mcknight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Clae, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Zillikens, M. Carola, Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., De Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Ander, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mad, Metspalu, Andre, Moebus, Susanne, Munroe, Patricia B., Njolstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Marku, Pérusse, Loui, Peters, Ulrike, Power, Chri, Quertermous, Thoma, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Slagboom, P. Eline, Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, Van Der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H. 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Holm, H., Iribarren, C., Jang, Y., Kähönen, M., Kee, F., Kim, HS., Klopp, N., Koenig, W., Kratzer, W., Kuulasmaa, K., Laakso, M., Laaksonen, R., Lind, L., Ouwehand, WH., Parish, S., Park, JE., Pedersen, NL., Peters, A., Quertermous, T., Rader, DJ., Salomaa, V., Schadt, E., Shah, SH., Sinisalo, J., Stark, K., Stefansson, K., Trégouët, DA., Virtamo, J., Wallentin, L., Wareham, N., Zimmermann, ME., Nieminen, MS., Hengstenberg, C., Sandhu, MS., Pastinen, T., Syvänen, AC., Hovingh, GK., Dedoussis, G., Franks, PW., Lehtimäki, T., Metspalu, A., Zalloua, PA., Siegbahn, A., Schreiber, S., Ripatti, S., Blankenberg, SS., Perola, M., Clarke, R., Boehm, BO., O'Donnell, C., Reilly, MP., März, W., Collins, R., Kathiresan, S., Hamsten, A., Kooner, JS., Thorsteinsdottir, U., Danesh, J., Palmer, CN., Roberts, R., Watkins, H., Schunkert, H., Samani, NJ., Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, CA., Fuchsberger, C., Olden, M., Chen, MH., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., 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GM., Ganna, A., Chen, J., Buchkovich, ML., Mora, S., Bragg-Gresham, JL., Chang, HY., Demirkan£££Ayşe£££ A., Den Hertog HM., Donnelly, LA., Ehret, GB., Feitosa, MF., Ferreira, T., Fraser, RM., Freitag, DF., Gurdasani, D., Heikkilä, K., Hyppönen, E., Jackson, AU., Johnson, T., Kaakinen, M., Kettunen, J., Li, X., Magnusson, PK., Mangino, M., Montasser, ME., Nolte, IM., Palmer, CD., Petersen, AK., Sanna, S., Saxena, R., Service, SK., Shah, S., Sidore, C., Surakka, I., Teslovich, TM., Van den Herik EG., Volcik, KA., Wong, A., Wu, Y., Asiki, G., Been, LF., Bolton, JL., Bonnycastle, LL., Burnett, MS., Cesana, G., Doring, A., Elliott, P., Eyjolfsson, GI., Goodarzi, MO., Grallert, H., Gravito, ML., Groves, CJ., Hartikainen, AL., Hicks, AA., Hung, YJ., Jones, MR., Kaleebu, P., Kastelein, JJ., Khaw, KT., Kim, E., Komulainen, P., Kumari, M., Lehtimaki, T., Lin, SY., Lindstrom, J., Mach, F., McArdle, WL., Muller, G., Nagaraja, R., Narisu, N., Nieminen, TV., Nsubuga, RN., Olafsson, I., Ong, KK., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Ridker, PM., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stančáková, A., Swift, AJ., Tiret, L., van Pelt, L., Vedantam, S., Wainwright, N., Wijmenga, C., Willemsen, G., Wilsgaard, T., Young, EH., Adair, LS., Bandinelli, S., Bennett, F., Boomsma, DI., Borecki, IB., Bornstein, SR., Bovet, P., Burnier, M., Chakravarti, A., Chen, YD., Collins, FS., Cooper, RS., Feranil, AB., Ferrieres, J., Freimer, NB., Gieger, C., Groop, LC., Hingorani, A., Hovingh, G., Hsiung, CA., Humphries, SE., Hunt, SC., Hveem, K., Jarvelin, MR., Jula, A., Kaprio, J., Kesäniemi, A., Kivimaki, M., Koudstaal, PJ., Krauss, RM., Kuh, D., Kyvik, KO., Lakka, TA., Lindgren, CM., McKenzie, CA., Meneton, P., Moilanen, L., Munroe, PB., Njølstad, I., Power, C., Price, JF., Rauramaa, R., Sanghera, DK., Saramies, J., Schwarz, PE., Sheu, WH., Spector, TD., Strachan, DP., Tayo, BO., Tremoli, E., Uusitupa, M., Whitfield, JB., Wolffenbuttel, BH., Ordovas, JM., Rich, SS., Mohlke, KL., Abecasis, GR., Abecasis, G., Caulfield, M., Chasman, D., Ehret, G., Johnson, A., Johnson, L., Larson, M., Levy, D., Munroe, P., Newton-Cheh, C., O'Reilly, P., Palmas, W., Psaty, B., Rice, K., Smith, A., Snider, H., Tobin, M., Van Duijn, C., Verwoert, G., Rice, KM., Tobin, MD., Verwoert, GC., Pihur, V., O'Reilly, PF., Amin, N., Launer, L., Aulchenko, Y., Heath, S., Sõber, S., Arora, P., Zhang, F., Lucas, G., Milaneschi, Y., Parker, AN., Fava, C., Fox, ER., Go, MJ., Sjögren, M., Vinay, D., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, PH., Shi, G., Tayo, B., Seielstad, M., Sim, X., Nguyen, KD., Matullo, G., Gaunt, TR., Onland-Moret, NC., Cooper, MN., Platou, CG., Org, E., Hardy, R., Dahgam, S., Palmen, J., Kuznetsova, T., Uiterwaal, CS., Adeyemo, A., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, ND., Garcia, M., Chang, YP., Steinle, NI., Grobbee, DE., Morrison, AC., Najjar, S., Hadley, D., Brown, MJ., Connell, JM., Hingorani, AD., Day, IN., Lawlor, DA., Beilby, JP., Lawrence, RW., Ongen, H., Li, Y., Young, JH., Bis, JC., Lee, NR., Bolton, JA., Chaturvedi, N., Frayling, TM., Islam, M., Jafar, TH., Kulkarni, SR., Grässler, J., Howard, P., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Weder, AB., Sun, YV., Bergman, RN., Scott, LJ., Stringham, HM., Peltonen, L., Vartiainen, E., Brand, SM., Staessen, JA., Wang, TJ., Burton, PR., Artigas, MS., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, KK., Rudock, ME., Heckbert, SR., Smith, NL., Wiggins, KL., Doumatey, A., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, CD., Rosengren, A., Thelle, DS., Corsi, AM., Singleton, A., Forrester, T., Hilton, G., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Cho, YS., Kim, HL., Scott, J., Sehmi, JS., Hedblad, B., Nilsson, P., Smith, GD., Raffel, LJ., Yao, J., Schwartz, SM., Ikram, M., Longstreth W. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
LOCI Genome-wide association study Continental Population Groups/genetics VARIANTS Body Mass Index Insulin Secretion Insulin Age Factor Adiposity ddc:616 Adipogenesis Genetic Predisposition to Disease/genetics Synapse 3. Good health Continental Population Group Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] GENOME-WIDE ASSOCIATIONPROVIDES INSIGHTSGLYCEMIC TRAITSLOCIMETAANALYSISVARIANTSINDIVIDUALSHIPPOCAMPALARCHITECTURETOPIRAMATE ddc:500 Adipogenesis/genetics Single Nucleotide/genetics Age Factors Continental Population Groups Energy Metabolism Europe Female Genetic Predisposition to Disease Glutamic Acid Humans Obesity Polymorphism Single Nucleotide Quantitative Trait Loci Synapses Genome-Wide Association Study Multidisciplinary genetics [Adiposity] Human Socio-culturale genetics [Energy Metabolism] ta3111 genetic body mass index obesity SDG 3 - Good Health and Well-being GLYCEMIC TRAITS genetics [Continental Population Groups] Genetic variability Polymorphism GENOME-WIDE ASSOCIATION genetics [Adipogenesis] METAANALYSIS Genetic association Adipogenesi genetics [Quantitative Trait Loci] ta1184 metabolism [Glutamic Acid] ta1182 PATHWAYS metabolism [Synapses] ta3121 medicine.disease metabolism [Insulin] Adiposity/genetics Clinical Medicine Quantitative Trait Loci/genetics Body mass index HUMAN HEIGHT BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA Synapses/metabolism Medizin Obesity/genetics Bioinformatics genetic basis Obesity/metabolism genetics [Obesity] body mass index (BMI) genetics [Genetic Predisposition to Disease] ethnology [Europe] 2. Zero hunger Genetics ARCHITECTURE Genetics of obesity Medicine (all) Single Nucleotide Polymorphism Single Nucleotide/genetics Insulin/metabolism/secretion Glutamic Acid/metabolism genetics [Polymorphism Single Nucleotide] EXPRESSION Insulin/metabolism PROVIDES INSIGHTS genetics [Racial Groups] Biology Obesity/genetics/metabolism Europe/ethnology metabolism [Obesity] Mendelian randomization medicine Energy Metabolism/genetics body mass genetic analysis obesity Klinisk medicin |
| Zdroj: | Nature, 518(7538), 197-206. Nature Publishing Group Locke, A E, Kahali, B, Berndt, S I, Justice, A E, Pers, T H, Day, F R, Powell, C, Vedantam, S, Buchkovich, M L, Yang, J, Croteau-Chonka, D C, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Maegi, R, Randall, J C, Winkler, T W, Wood, A R, Workalemahu, T, Faul, J D, Smith, J A, Zhao, J H, Zhao, W, Chen, J, Fehrmann, R, Hedman, A K, Karjalainen, J, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, J L, Bragg-Gresham, L, Buyske, S, Demirkan, A, Deng, G, Ehret, G B, Feenstra, B, Feitosa, M F, Fischer, K, Goel, A, Gong, J, Jackson, A U, Kanoni, S, Kleber, M E, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Leach, I M, Medina-Gomez, C, Medland, S E, Nalls, M A, Palmer, C D, Pasko, D, Pechlivanis, S, Peters, MJ, Prokopenko, I, Shungin, D, Stancakova, A, Strawbridge, R J, Sung, Y J, Teumer, A, Trompet, S, van der Laan, S W, van Settee, J, Van Vliet-Ostaptchouk, J V, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Arnlov, J, Arscott, G M, Attwood, A P, Bandinelli, S, Barrett, A, Bas, I N, Bellis, C, Bennett, A J, Berne, C, Blagieva, R, Blueher, M, Bohringer, S, Bonnycastle, L L, Boettcher, Y, Boyd, H A, Bruinenberg, M, Caspersen, I H, Chen, Y I, Clarke, R, Daw, E W, de Craen, A J M, Delgado, G, Dimitriou, M, Doney, A S F, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, R M, Garcia, M E, Geller, F, Giedraitis, V, Gigante, B, Go, A S, Golay, A, Goodall, A H, Gordon, S D, Gorski, M, Grabe, H, Grallert, H, Grammer, T B, Graessler, J, Gronberg, H, Groves, C J, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, C A, Hassinen, M, Hayward, C, Heard-Costa, N L, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J J, James, A L, Jeff, J M, Johansson, A, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, N R, Lichtner, P, Lind, L, Lindstrom, J, Lo, K S, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, P K E, Mahajan, A, McArdle, W L, McLachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, K L, Morken, M A, Mulas, A, Mueller, G, Mueller-Nurasyid, M, Musk, A W, Nagaraja, R, Noethen, M M, Nolte, I M, Pilz, S, Rayner, N W, Renstrom, F, Rettig, R, Ried, J S, Ripke, S, Robertson, N R, Rose, L M, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, F R, Scott, W R, Seufferlein, T, Shi, J, Smith, A V, Smolonska, J, Stanton, A V, Steinthorsdottir, V, Stirrups, K, Stringham, H M, Sundstrom, J, Swertz, M A, Swift, A J, Syvanen, A, Tan, S, Tayo, B O, Thorand, B, Thorleifsson, G, Tyrer, J P, Uh, H, Vandenput, L, Verhulst, F C, Vermeulen, S H, Verweij, N, Vonk, J M, Waite, L L, Warren, H R, Waterworth, D, Weedon, M N, Wilkens, L R, Willenborg, C, Wilsgaard, T, Wojczynski, M K, Wong, A, Wrightl, A F, Zhang, Q, Brennan, E P, Choi, M, Dastani, Z, Drong, A W, Eriksson, P, Franco-Cereceda, A, Gadin, J R, Gharavi, A G, Goddard, M E, Handsaker, R E, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J, Liang, L, Lifton, R P, Ma, B, McCarroll, S A, McKnight, A J, Min, J L, Moffatt, M F, Montgomery, G W, Murabito, J M, Nicholson, G, Nyholt, DR, Okada, Y, Perry, J R B, Dorajoo, R, Reinmaa, E, Salem, R M, Sandholm, N, Scott, R A, Stolk, L, Takahashi, A, Tanaka, T, van 't Hooft, F M, Vinkhuyzen, A A E, Westra, H, Zheng, W, Zondervan, K T, Heath, A C, Arveiler, D, Bakker, S J L, Beilby, J, Bergman, R N, Blangero, J, Bovet, P, Campbell, H, Caulfield, M J, Cesana, G, Chakravarti, A, Chasman, D I, Chines, P S, Collins, F S, Crawford, D C, Cupples, L A, Cusi, D, Danesh, J, de Faire, U, den Ruijter, H M, Dominiczak, A F, Erbel, R, Erdmann, J, Eriksson, J G, Farrall, M, Felix, S B, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, N G, Forrester, T, Franco, O H, Gansevoort, R T, Gejman, P V, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, A S, Harris, T B, Hattersley, A T, Hicks, A A, Hindorff, L A, Hingorani, A D, Hofman, A, Homuth, G, Hovingh, G K, Humphries, S E, Hunt, S C, Hypponen, E, Illig, T, Jacobs, K B, Jarvelin, M, Joeckel, K, Johansen, B, Jousilahti, P, Jukema, J W, Jula, A M, Kaprio, J, Kastelein, J J P, Keinanen-Kiukaanniemi, S M, Kiemeney, L A, Knekt, P, Kooner, J S, Kooperberg, C, Kovacs, P, Kraja, A T, Kumari, M, Kuusisto, J, Lakka, T A, Langenberg, C, Le Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T C, McKenzie, C A, McKnight, B, Moll, F L, Morris, A D, Morris, A P, Murray, J C, Nelis, M, Ohlsson, C, Oldehinkel, A J, Ong, K K, Madden, P A F, Pasterkamp, G, Peden, J F, Peters, A, Postma, D S, Pramstaller, P P, Price, J F, Qi, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Ridker, P M, Rioux, J D, Ritchie, M D, Rudan, I, Salomaa, V, Samani, N J, Saramines, J, Sarzynski, M A, Schunkert, H, Schwarz, P E H, Sever, P, Shuldiner, A R, Sinisalo, J, Stolk, R P, Strauch, K, Toenjes, A, Tregouet, D, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M, Voelker, U, Waeber, G, Willemsen, G, Witteman, J C, Zillikens, M C, Adair, L S, Amouyel, P, Asselbergs, F W, Assimes, T L, Bochud, M, Boehm, B O, Boerwinkle, E, Bornstein, S R, Bottinger, E P, Bouchard, C, Cauchi, S, Chambers, J C, Chanock, S J, Cooper, R S, de Bakker, P I W, Dedoussis, G, Ferrucci, L, Franks, P W, Froguel, P, Groop, L C, Haiman, C A, Hamsten, A, Hui, J, Hunter, D J, Hveem, K, Kaplan, R C, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, N G, Maerz, W, Melbve, M, Metspalu, A, Moebus, S, Munroe, P B, Njolstad, I, Oostra, B A, Palmer, C N A, Pedersen, N L, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T E, Saleheen, D, Sattar, N, Schadt, E E, Schlessinger, D, Slagboom, P E, Snieder, H, Spector, T D, Thorsteinsdottir, U R, Stumvoll, M, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van der Harst, P, Walker, M, Wallaschofski, H, Wareham, N J, Watkins, H, Weir, D R, Wichmann, H, Wilson, J F, Zanen, P, Borecki, I B, Deloukas, P, Fox, C S, Heid, I M, O'Connell, J R, Strachan, D P, Stefansson, K, van Duijri, C M, Abecasis, G R, Franke, L, Frayling, T M, McCarthy, M I, Visscher, P M, Scherag, A, Willer, C J, Boehnke, M, Mohlke, K L, Lindgren, C M, Beckmann, J S, Barroso, I, North, K E, Ingelsson, E, Hirschhorn, J N, Loos, R J F & Speliotes, E K 2015, ' Genetic studies of body mass index yield new insights for obesity biology ', Nature, vol. 518, no. 7538, pp. 197-206 . https://doi.org/10.1038/nature14177 Nature, 518(7538), 197. Nature Publishing Group Nature Nature, 518(7538), 197-U401 Nature, Vol. 518, No 7538 (2015) pp. 197-206 Nature, vol. 518, no. 7538, pp. 197-206 Nature Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Locke, A E, Kahali, B, Berndt, S I, Justice, A E, Pers, T H, Day, F R, Powell, C, Vedantam, S, Buchkovich, M L, Yang, J, Croteau-Chonka, D C, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Maegi, R, Randall, J C, Winkler, T W, Wood, A R, Workalemahu, T, Faul, J D, Smith, J A, Zhao, J H, Zhao, W, Chen, J, Fehrmann, R, Hedman, A K, Karjalainen, J, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M & Bolton, J L & Bragg-Gresham, L & Buyske, S & Demirkan, A & Deng, G & Fraser, R M & Hayward, C & McLachlan, S & Campbell, H & Morris, A D & Price, J F & Rudan, I & Walker, M & Wilson, J F & Visscher, P M 2015, ' Genetic studies of body mass index yield new insights for obesity biology ', Nature, vol. 518, no. 7538, pp. 197-U401 . https://doi.org/10.1038/nature14177 Nature, 518(7538), 197-U401. Nature Publishing Group Nature, 518, 7538, pp. 197-206 Nature, 518, 197-206 |
| ISSN: | 0028-0836 |
| DOI: | 10.1038/nature14177 |
| Popis: | Item does not contain fulltext Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for approximately 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
| Databáze: | OpenAIRE |
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