Effects of recombinant human bone morphogenetic protein-2 compared to other biomaterials in the treatment of intrabony defects in periodontitis patients: A systematic review
| Autor: | Kumar Ankit Sinha, Vinayak Venkoosa Meharwade, Raghavendra Shrishail Medikeri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
recombinant human bone morphogenetic protein-2
medicine.medical_treatment MEDLINE Dentistry Human bone Review Article Bone morphogenetic protein 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Bone morphogenetic proteins periodontal regeneration medicine In patient Bone regeneration Reduction (orthopedic surgery) Periodontitis business.industry intrabony defects 030206 dentistry medicine.disease lcsh:RK1-715 lcsh:Dentistry Debridement (dental) Periodontics business |
| Zdroj: | Journal of Indian Society of Periodontology Journal of Indian Society of Periodontology, Vol 23, Iss 4, Pp 311-315 (2019) |
| ISSN: | 0972-124X |
| Popis: | Background: Bone morphogenetic proteins have a powerful osteoinductive capacity and have been used as a new adjunct to graft materials for bone regeneration. The objectives of this systematic review are to assess the amount of radiographic bone fill, clinical attachment level (CAL) gain, and reduction in pocket depth (PD) in patients with intrabony defects in periodontitis patients following the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Materials and Methods: Electronic bibliographic databases search of Medline, Science Direct, and Google Scholar was made from January 1980 to December 2017. Studies using rhBMP-2 to treat periodontal intrabony defects of the maxillary or mandibular region with follow-up period of at least 6 months were searched. Two reviewers performed the systematic review using the PRISMA Statement for reporting and the Cochrane risk-of-bias tool was used for quality assessment. Results: It was found that rhBMP-2 showed statistically significant results with respect to radiographic defect resolution, CAL, and PD reduction at 9 months compared to open-flap debridement but showed statistically significant results only with respect to radiographic bone fill when compared with platelet-rich fibrin at 6 months. Conclusion: The rhBMP-2 may provide a promising alternative to traditional grafting procedures therapy that can enhance periodontal regeneration in patients having intrabony defects. Due to limited human studies, it can be concluded that no definitive evidence exists to ascertain the effectiveness of rhBMP-2 in the treatment of intrabony defects in periodontal diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|