Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
| Autor: | Kit Melissa Larsen, Ilvana Dzafic, Suresh Sundram, Holly Pertile, Olivia Carter, Marta I. Garrido, Hayley Darke |
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| Rok vydání: | 2020 |
| Předmět: |
Auditory perception
Psychosis Schizotypy Bayesian probability Internal model Mismatch negativity Context (language use) Electroencephalography 03 medical and health sciences 0302 clinical medicine medicine Humans Biological Psychiatry Continuum (measurement) medicine.diagnostic_test Dynamic causal modelling Bayes Theorem medicine.disease 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Schizophrenia Auditory Perception Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Schizophrenia Research. 222:185-194 |
| ISSN: | 0920-9964 |
| Popis: | BackgroundThe ability to generate a precise internal model of statistical regularities is impaired in schizophrenia. Predictive coding accounts of schizophrenia suggest that psychotic symptoms may be explained by a failure to build precise beliefs or a model of the world. The precision of this model may vary with context. For example, in a noisy environment the model will be more imprecise compared to a model built in an environment with lower noise. However compelling, this idea has not yet been empirically studied in schizophrenia. Methods: In this study, 62 participants engaged in a stochastic mismatch negativity paradigm with high and low precision. We included inpatients with a schizophrenia spectrum disorder (N=20), inpatients with a psychiatric disorder but without psychosis (N=20), and healthy controls (N=22), with comparable sex ratio and age distribution. Bayesian mapping and dynamic causal modelling were employed to investigate the underlying microcircuitry of precision encoding of auditory stimuli. Results: We found strong evidence (exceedance p > 0.99) for differences in the underlying connectivity associated with precision encoding between the three groups as well as on the continuum of psychotic-like experiences assessed across all participants. Critically, we show changes in interhemispheric connectivity between the two inpatient groups, with some connections further aligning on the continuum of psychotic-like experiences. Conclusions: While our results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations. |
| Databáze: | OpenAIRE |
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