Risk factors for candidemia after open heart surgery: Results from a multicenter case-control study
| Autor: | Maddalena Giannella, Valerio Del Bono, Alberto Enrico Maraolo, Antonio Salsano, Francesca Raffaelli, Daniele Roberto Giacobbe, Beatrice Maccari, Filippo Del Puente, Michele Bartoletti, Antonio Vena, Renato Pascale, Alessia Carnelutti, Mario Tumbarello, Davide Ricci, Elisa Mikus, Alice Annalisa Medaglia, Silvia Corcione, Tommaso Lupia, Francesco Giuseppe De Rosa, Marco Comaschi, Alessandra Mularoni, Ambra Miette, Elena Conoscenti, Angela Raffaella Losito, Matteo Bassetti, Ivan Gentile, Malgorzata Mikulska, Francesco Santini, Stefano Frisone, Maddalena Peghin |
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| Přispěvatelé: | Giacobbe, D. R., Salsano, A., Del Puente, F., Miette, A., Vena, A., Corcione, S., Bartoletti, M., Mularoni, A., Maraolo, A. E., Peghin, M., Carnelutti, A., Losito, A. R., Raffaelli, F., Gentile, I., Maccari, B., Frisone, S., Pascale, R., Mikus, E., Medaglia, A. A., Conoscenti, E., Ricci, D., Lupia, T., Comaschi, M., Giannella, M., Tumbarello, M., de Rosa, F. G., Bono, V. D., Mikulska, M., Santini, F., Bassetti, M., Giacobbe D.R., Salsano A., Del Puente F., Miette A., Vena A., Corcione S., Bartoletti M., Mularoni A., Maraolo A.E., Peghin M., Carnelutti A., Losito A.R., Raffaelli F., Gentile I., Maccari B., Frisone S., Pascale R., Mikus E., Medaglia A.A., Conoscenti E., Ricci D., Lupia T., Comaschi M., Giannella M., Tumbarello M., de Rosa F.G., Bono V.D., Mikulska M., Santini F., Bassetti M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Carbapenem Bloodstream infection Major Articles law.invention 03 medical and health sciences Postoperative complications 0302 clinical medicine Interquartile range law Candida bloodstream infection cardiac surgery postoperative complications medicine Cardiopulmonary bypass 030212 general & internal medicine business.industry Septic shock Case-control study 030208 emergency & critical care medicine Odds ratio Cardiac surgery medicine.disease Intensive care unit Surgery AcademicSubjects/MED00290 Infectious Diseases Oncology business medicine.drug |
| Zdroj: | Open Forum Infectious Diseases |
| Popis: | Background Candida species are among the most frequent causative agents of health care–associated bloodstream infections, with mortality >40% in critically ill patients. Specific populations of critically ill patients may present peculiar risk factors related to their reason for intensive care unit admission. The primary objective of the present study was to assess the predictors of candidemia after open heart surgery. Methods This retrospective, matched case–control study was conducted in 8 Italian hospitals from 2009 to 2016. The primary study objective was to assess factors associated with the development of candidemia after open heart surgery. Results Overall, 222 patients (74 cases and 148 controls) were included in the study. Candidemia developed at a median time (interquartile range) of 23 (14–36) days after surgery. In multivariable analysis, independent predictors of candidemia were New York Heart Association class III or IV (odds ratio [OR], 23.81; 95% CI, 5.73–98.95; P Conclusions Previous broad-spectrum antibiotic therapy and high NYHA class were independent predictors of candidemia in cardiac surgery patients with prolonged postoperative intensive care unit stay. |
| Databáze: | OpenAIRE |
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