Failure of cervical fibronectin to predict premature delivery in a population of monofetal pregnancies with idiopathic preterm labor
| Autor: | Virginie Doridot, Jean-François Oury, Jean Guibourdenche, Jean-Luc Voluménie, Philippe Blot, Olivier Sibony, Dominique Luton |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Pediatrics Time Factors Preterm labor Population Tocolysis Gestational Age Cervix Uteri Sensitivity and Specificity Continuous variable symbols.namesake Obstetric Labor Premature Pregnancy medicine Humans Longitudinal Studies Prospective Studies education Fisher's exact test Preterm delivery education.field_of_study biology Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology Length of Stay Delivery Obstetric Predictive value Fibronectins Outcome parameter Fibronectin Reproductive Medicine symbols biology.protein Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 97:35-39 |
| ISSN: | 0301-2115 |
| Popis: | Objective: The purpose of the study was to evaluate the correlation between the presence of cervical fibronectin in a high-risk population of women with symptoms of preterm labor and the occurrence of preterm delivery or the need for aggressive tocolysis. Study design: One hundred and thirty women presenting with symptoms of threatened preterm labor were included. Cervical sampling for detection of fibronectin was performed on admission and every day until discharge or delivery. Time to delivery, length of hospital stay, use of indomethacin, delivery before 37 weeks of GA, mean term of delivery and failure of tocolysis to prevent delivery were compared to fibronectin test results. Data were analyzed using Student’s t-test for continuous variables and the χ2 test or Fisher exact test for discrete variables. Results: No correlation could be found between the results of fibronectin cervical sampling on admission and any of the outcome parameters studied. Test performances were low (sensitivity 28%, specificity 57%, positive predictive value 19%, negative predictive value 69%). Results were not modified when the findings of repeated tests were taken into account. Conclusion: Cervical fibronectin failed to discriminate a subgroup of symptomatic women delivering prematurely. The prognostic value of fibronectin testing was not better than clinical data in our series. This observation is in disagreement with previous studies on the diagnostic value of vaginal or cervical fibronectin in preterm labor. |
| Databáze: | OpenAIRE |
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