A summer camp for boys with hemophilia
| Autor: | John J. Miller, Julia B. Ashenhurst, Ruth Andrea Seeler |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Fetus Pediatrics medicine.medical_specialty Adolescent business.industry Physiology Locus (genetics) Southeast asian medicine.disease Hemophilia A Hemoglobin Barts Cord blood Hydrops fetalis Pediatrics Perinatology and Child Health Camping Trait Summer camp Medicine Humans Illinois business Child Attitude to Health Sports |
| Zdroj: | The Journal of pediatrics. 87(5) |
| ISSN: | 0022-3476 |
| Popis: | By age six months, production of 7-globin chains approaches adult levels and hemoglobin Bart is not detectable in patients with a-thalassemia. Since tetramers of fi-chains (hemoglobin H) are not present in high enough quantity to be detected by routine electrophoretic techniques in a-thalassemia trait, the neonatal period offers a unique opportunity to detect a-thalassemi a by electrophoresis. Detection of microcytic red blood cells during the first few days of life has als0 been used to screen for a-thalassemia trait but requires confirmation by electrophoresis. TM Our studies have demonstrated the occurrence of athalassemia trait in about 5% of Filipinos. This can be expected to result in a fetal wastag e due to homozygous athalassemia in about one of every 1,600 conceptions. This suggests that Filipinos commonly have a double-locus defect similar to that found in southeast Asian and Indonesian populations. In contrast, about 2% of black Americans have Hgb Bart in their cord blood. 1 Bart hydrops fetalis has not been reported in this group. Perhaps blacks have only a single a-chain locus defect. |
| Databáze: | OpenAIRE |
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