Risk of death after first-time blood stream infection in incident dialysis patients with specific consideration on vascular access and comorbidity

Autor: Gunnar Hellmund Laier, James G. Heaf, Karl Emil Nelveg-Kristensen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_treatment
030232 urology & nephrology
Bacteremia
Comorbidity
030204 cardiovascular system & hematology
0302 clinical medicine
Renal Dialysis/adverse effects
Risk Factors
Cause of Death
Central Venous Catheters
Aged
80 and over
Incidence
Middle Aged
Blood stream infection
Catheter-Related Infections/blood
Infectious Diseases
Female
Hemodialysis
Peritoneal Dialysis
Research Article
Adult
medicine.medical_specialty
Adolescent
Peritoneal Dialysis/adverse effects
Vascular access
Central Venous Catheters/microbiology
Dialysis modality
Peritoneal dialysis
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Young Adult
Renal Dialysis
Internal medicine
medicine
Humans
lcsh:RC109-216
Risk factor
Mortality
Dialysis
Aged
Retrospective Studies
business.industry
Bacteremia/epidemiology
Retrospective cohort study
Stepwise regression
medicine.disease
Risk factors
Catheter-Related Infections
business
Zdroj: Nelveg-Kristensen, K E, Laier, G H & Heaf, J G 2018, ' Risk of death after first-time blood stream infection in incident dialysis patients with specific consideration on vascular access and comorbidity ', BMC Infectious Diseases, vol. 18, 688 . https://doi.org/10.1186/s12879-018-3594-7
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Infectious Diseases
DOI: 10.1186/s12879-018-3594-7
Popis: Background The mortality following blood stream infection (BSI) and risk of subsequent BSI in relation to dialysis modality, vascular access, and other potential risk factors has received relatively little attention. Consequently, we assessed these matters in a retrospective cohort study, by use of the Danish nation-wide registries. Methods Patients more than 17 years of age, who initiated dialysis between 1.1.2010 and 1.1.2014, were grouped according to their dialysis modality and vascular access. Survival was modeled in time-dependent Cox proportional hazard analyses. Potential risk factors confined by a modified Charlson comorbidity index (MCCI), were subsequently assessed in stepwise selection models. Results At baseline, 764 patients received peritoneal dialysis (PD), and 434, 479, and 782 hemodialysis (HD) patients were dialyzed by use of arteriovenous fistulas (AVFs), tunneled catheters (TCs), and non-tunneled catheters (NTCs), respectively. We identified 1069 BSIs with an overall incidence rate of 17.7 episodes per 100 person years, and 216 BSIs occurred more than one time in the same patient. HRs of post BSI mortality relative to PD were 3.20 (95% CI 1.86–5.50; p
Databáze: OpenAIRE
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