Cerebellar control of gait and interlimb coordination
| Autor: | Robert M. Seepers, Chris I. De Zeeuw, Jan-Willem Potters, Kuikui Zhou, María Fernanda Vinueza Veloz, Laurens W. J. Bosman, Christos Strydis, Sebastiaan K. E. Koekkoek, Mario Negrello |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Histology Interneuron Neuroscience(all) Purkinje cell Mice Transgenic Interlimb coordination 03 medical and health sciences Erasmus Ladder Mice Purkinje Cells 0302 clinical medicine Interneurons medicine Avoidance Learning Animals Gait 030304 developmental biology 0303 health sciences Motivation General Neuroscience Long-term potentiation Granule cell Adaptation Physiological Mice Inbred C57BL medicine.anatomical_structure Eyeblink conditioning Cerebellar cortex Reflex Original Article Female Anatomy Motor learning Psychology Neuroscience 030217 neurology & neurosurgery Granule cells Locomotion |
| Zdroj: | Brain Structure & Function Brain Structure & Function, 220(6), 3513-36. Springer Verlag GmbH Brain Structure & Function, 220(6), 3513-3536. Springer-Verlag Brain Structure and Function |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | Synaptic and intrinsic processing in Purkinje cells, interneurons and granule cells of the cerebellar cortex have been shown to underlie various relatively simple, single-joint, reflex types of motor learning, including eyeblink conditioning and adaptation of the vestibulo-ocular reflex. However, to what extent these processes contribute to more complex, multi-joint motor behaviors, such as locomotion performance and adaptation during obstacle crossing, is not well understood. Here, we investigated these functions using the Erasmus Ladder in cell-specific mouse mutant lines that suffer from impaired Purkinje cell output (Pcd), Purkinje cell potentiation (L7-Pp2b), molecular layer interneuron output (L7-Δγ2), and granule cell output (α6-Cacna1a). We found that locomotion performance was severely impaired with small steps and long step times in Pcd and L7-Pp2b mice, whereas it was mildly altered in L7-Δγ2 and not significantly affected in α6-Cacna1a mice. Locomotion adaptation triggered by pairing obstacle appearances with preceding tones at fixed time intervals was impaired in all four mouse lines, in that they all showed inaccurate and inconsistent adaptive walking patterns. Furthermore, all mutants exhibited altered front–hind and left–right interlimb coordination during both performance and adaptation, and inconsistent walking stepping patterns while crossing obstacles. Instead, motivation and avoidance behavior were not compromised in any of the mutants during the Erasmus Ladder task. Our findings indicate that cell type-specific abnormalities in cerebellar microcircuitry can translate into pronounced impairments in locomotion performance and adaptation as well as interlimb coordination, highlighting the general role of the cerebellar cortex in spatiotemporal control of complex multi-joint movements. Electronic supplementary material The online version of this article (doi:10.1007/s00429-014-0870-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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