Exposure to anticholinergic and sedative medications using the Drug Burden Index and its association with vertigo, dizziness and balance problems in older people - Results from the KORA-FF4 Study
Autor: | Birgit Linkohr, Margit Heier, Ralf Strobl, Rolf Holle, Amanda Phillips, Eva Grill, Annette Peters |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Risk Aging Population ageing Pediatrics medicine.medical_specialty medicine.drug_class Logistic regression Biochemistry Dizziness Cholinergic Antagonists 03 medical and health sciences 0302 clinical medicine Endocrinology Vertigo Germany Genetics Anticholinergic medicine Humans Hypnotics and Sedatives Molecular Biology Postural Balance Aged Aged 80 and over biology business.industry Drug Burden Index Sedative Cell Biology Odds ratio biology.organism_classification 030104 developmental biology Cross-Sectional Studies Logistic Models Ambulatory Multivariate Analysis Female medicine.symptom Risk assessment business 030217 neurology & neurosurgery Balance problems |
Zdroj: | Exp. Gerontol. 124:110644 (2019) |
ISSN: | 1873-6815 |
Popis: | Aims This study examines exposure to anticholinergic and sedative (AS) medications in the general aging population using the Drug Burden Index (DBI) and to analyze the association of AS burden with vertigo, dizziness and balance problems (VDB, primary outcome) and falls (secondary outcome). Methods We performed a cross-sectional analysis of data from the second follow-up (FF4) in 2013/14 of the Cooperative Health Research in the Region of Augsburg (KORA)-S4 study. AS burden was classified as DBI > 0. Self-reported data of VDB and falls during the previous 12 months were collected. Multivariable logistic regression was used to estimate the association of AS burden with VDB and falls. Results 883 participants were included in this study (mean age 73.8 years, 48.4% female). AS burden was present in 167 (18.9%) participants, with the highest prevalence in those aged ≥80 years old (26.3%). In the adjusted analysis, AS burden was independently and significantly associated with VDB (Adjusted Odds Ratio (AOR): 1.73 [95% CI: 1.16, 2.56]). Conclusion This study provides reliable prevalence estimates of AS burden in older people using the DBI in Germany, also indicating a positive and significant association with VDB. As VDB are among the main reasons for falls, we do recommend including the AS burden calculation as routine risk assessment in ambulatory medical care. |
Databáze: | OpenAIRE |
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