The recovery of standing and locomotion after spinal cord injury does not require task-specific training
| Autor: | Emmanuelle de Vette, N. Gaudreault, Jonathan Harnie, Etienne Desrochers, Johannie Audet, Alain Frigon, Adam Doelman |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine functional recovery Stimulation Hindlimb 0302 clinical medicine Feedback Sensory Biology (General) Spinal cord injury CATS General Neuroscience Central pattern generator Cat General Medicine task-specificity Spinal Cord Medicine Female Locomotion Research Article medicine.medical_specialty QH301-705.5 Science Sensory system Treadmill training General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Physical medicine and rehabilitation Physical Conditioning Animal medicine Animals Felis catus Muscle Skeletal Sensory cue Spinal Cord Injuries General Immunology and Microbiology Electromyography business.industry Extremities Recovery of Function medicine.disease spinal cord injury Walking Speed locomotor training central pattern generator Disease Models Animal 030104 developmental biology Cats Other business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | After complete spinal cord injury, mammals, including mice, rats and cats, recover hindlimb locomotion with treadmill training. The premise is that sensory cues consistent with locomotion reorganize spinal sensorimotor circuits. Here, we show that hindlimb standing and locomotion recover after spinal transection in cats without task-specific training. Spinal-transected cats recovered full weight bearing standing and locomotion after five weeks of rhythmic manual stimulation of triceps surae muscles (non-specific training) and without any intervention. Moreover, cats modulated locomotor speed and performed split-belt locomotion six weeks after spinal transection, functions that were not trained or tested in the weeks prior. This indicates that spinal networks controlling standing and locomotion and their interactions with sensory feedback from the limbs remain largely intact after complete spinal cord injury. We conclude that standing and locomotor recovery is due to the return of neuronal excitability within spinal sensorimotor circuits that do not require task-specific activity-dependent plasticity. |
| Databáze: | OpenAIRE |
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