The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication
| Autor: | Ahmad Hosseinzadeh, Amir Hossein Meisami, Milad Abbasi, Kazem Jamali, Ali Jangjou, Ahmad Vaez, Mohammad Hadi Niakan, Majid Salehi, Ali Mohammad Amani, Mostafa Shafiee |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Contrast Media Review 02 engineering and technology Disease 03 medical and health sciences Drug Delivery Systems medicine Pharmacology (medical) Disease Eradication Intensive care medicine Molecular Biology Ultrasonography media_common Microbubbles business.industry Biochemistry (medical) Cancer Cell Biology General Medicine 021001 nanoscience & nanotechnology medicine.disease Biocompatible material Cancer treatment Biomedicine 030104 developmental biology Drug delivery Medicine Nanoparticles 0210 nano-technology business Drug carrier |
| Zdroj: | Journal of Biomedical Science Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-24 (2021) |
| ISSN: | 1423-0127 |
| DOI: | 10.1186/s12929-021-00744-4 |
| Popis: | Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the microbubble is surrounded by a membrane that may consist of biocompatible biopolymers, polymers, surfactants, proteins, lipids, or a combination thereof. One of the most effective implementation techniques for tiny bubbles is to apply them as a drug carrier that has the potential to activate ultrasound (US); this allows the drug to be released by US. Microbubbles are often designed to preserve and secure medicines or substances before they have reached a certain area of concern and, finally, US is used to disintegrate microbubbles, triggering site-specific leakage/release of biologically active drugs. They have excellent therapeutic potential in a wide range of common diseases. In this article, we discussed microbubbles and their advantageous medicinal uses in the treatment of certain prevalent disorders, including Parkinson's disease, Alzheimer's disease, cardiovascular disease, diabetic condition, renal defects, and finally, their use in the treatment of various forms of cancer as well as their incorporation with nanoparticles. Using microbubble technology as a novel carrier, the ability to prevent and eradicate prevalent diseases has strengthened the promise of effective care to improve patient well-being and life expectancy. |
| Databáze: | OpenAIRE |
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