Liposome-encapsulated antibiotics: preparation, drug release and antimicrobial activity againstPseudomonas aeruginosa
| Autor: | Jacqueline Lagacé, Serge Montplaisir, Martine Dubreuil |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.drug_class
Chemistry Pharmaceutical Drug Compounding Antibiotics Pharmaceutical Science Bioengineering Pharmacology Biology medicine.disease_cause Microbiology Minimum inhibitory concentration Colloid and Surface Chemistry Drug Stability medicine Tobramycin Ticarcillin Physical and Theoretical Chemistry Antibacterial agent Drug Carriers Pseudomonas aeruginosa Organic Chemistry Aminoglycoside Drug Resistance Microbial Antimicrobial Anti-Bacterial Agents Liposomes medicine.drug |
| Zdroj: | Journal of Microencapsulation. 8:53-61 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652049109021857 |
| Popis: | Ticarcillin- and tobramycin-resistant strains of Pseudomonas aeruginosa were shown to have a markedly increased sensitivity to antibiotics enclosed in liposomes. This was demonstrated by growth inhibition of two resistant P. aeruginosa strains in the presence of the liposome-enclosed ticarcillin and tobramycin at 2 per cent and 20 per cent of their respective minimum inhibitory concentration. The liposome-enclosed antibiotic was as effective against the beta-lactamase-producing strain as against the non-beta-lactamase producing strain. Entrapment efficiency of the two antibiotics with the dehydration-rehydration vesicle (DRV) method was largely superior to other methodologies used. Kinetic studies with DRV demonstrated that tobramycin and ticarcillin-loaded liposomes still contained 83 per cent and 67 per cent of drug respectively after 24 h at 37 degrees C. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|