The Association between Behavioral Risk Factors and Nontuberculous Mycobacterial Pulmonary Disease
| Autor: | Se Hyun Kwak, Su Hwan Lee, Young Sam Kim, Young Mok Park, Moo Suk Park, Sang Hoon Lee, Ah Young Leem, Young Ae Kang, Kyung Soo Chung, Ji Ye Jung, Song Yee Kim, Joon Chang, Eun Young Kim, Seung Hyun Yong |
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| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
medicine.medical_specialty Multivariate analysis Seoul environmental exposure Subgroup analysis Logistic regression nontuberculous mycobacterium infection Risk Factors Internal medicine Republic of Korea medicine Humans Aged biology business.industry Medical record Nontuberculous Mycobacteria General Medicine Environmental exposure Odds ratio Middle Aged Mycobacterium avium Complex biology.organism_classification Confidence interval Pulmonology & Critical Care Medicine Original Article Female Nontuberculous mycobacteria business |
| Zdroj: | Yonsei Medical Journal |
| ISSN: | 1976-2437 0513-5796 |
| DOI: | 10.3349/ymj.2021.62.8.702 |
| Popis: | Purpose We aimed to determine the relationship between environmental exposure and nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea. Materials and methods A group of 150 patients with NTM-PD and a control group of 217 patients with other respiratory diseases were prospectively enrolled between June 2018 and December 2020 in Seoul, Korea. They were surveyed with a standardized questionnaire, and their medical records were reviewed. Odds ratio (OR) and 95% confidence intervals (CI) were calculated with multivariate logistic regression analysis. Results The mean ages of the NTM-PD and control groups were similar (63.8±9.2 years vs. 63.5±10.0 years; p=0.737), and most patients were female (76.0% vs. 68.7%; p=0.157) and nonsmokers (82.0% vs. 72.8%; p=0.021). Mycobacterium avium (49.3%) was the most commonly identified strain among NTM-PD patients, followed by M. intracellulare (32.0%) and M. abscessus subspecies massiliense (12.7%). There were no differences in housing type or frequency of soil- or pet-related exposure between the case and the control groups. However, in subgroup analysis excluding patients with M. intracellulare infection, more case patients frequently visited public baths ≥1 time/week (35.3% vs. 19.4%, p=0.003); this remained significant after multivariate analysis (OR, 2.84; 95% CI, 1.58-5.17). Conclusion Frequent exposure to water at public baths might affect the odds of contracting NTM-PD, excluding individuals infected with M. intracellulare strains. |
| Databáze: | OpenAIRE |
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