Investigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern
| Autor: | Melissa Van Bossuyt, Tara Vandermarken, Adrian Covaci, Marc Elskens, Birgit Mertens, Karin Vandermeiren, Marie-Louise Scippo, Luc Verschaeve, Els Van Hoeck, Coraline Simon, Matthias Onghena, Joris Van Loco, Kersten Van Langenhove, Heidi Demaegdt |
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| Přispěvatelé: | Faculty of Medicine and Pharmacy, Pharmaceutical and Pharmacological Sciences, Experimental in vitro toxicology and dermato-cosmetology, Chemistry, Earth System Sciences, Analytical, Environmental & Geo-Chemistry, Analytical and Environmental Chemistry |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Bisphenol A Food contact materials Food Contamination 010501 environmental sciences Biology Toxicology medicine.disease_cause ECHA Database 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Phenols medicine European market Humans Benzhydryl Compounds 0105 earth and related environmental sciences Polycarboxylate Cement business.industry Pharmacology. Therapy VITOTOX Infant General Medicine Biotechnology 030104 developmental biology Polycarbonate replacement products Endocrine disruptor chemistry in silico DNA damage business Relevant information Genotoxicity Food Science Mutagens |
| Zdroj: | Food and chemical toxicology |
| ISSN: | 1873-6351 0278-6915 |
| Popis: | Due to the worldwide concern that bisphenol A might act as an endocrine disruptor, alternative materials for polycarbonate (PC) have been introduced on the European market. However, PC -replacement products might also release substances of which the toxicological profile including their genotoxic effects has not yet been. characterized. Because a thorough characterization of the genotoxic profile of all these substances is impossible in the short term, a strategy was developed in order to prioritize those substances for which additional data are urgently needed. The strategy consisted of a decision tree using hazard information related to genotoxicity. The relevant information was obtained from the database of the European Chemicals Agency (ECHA), in silico prediction tools (ToxTree and Derek NexusTM) and the in vitro Vitotox test for detecting DNA damage. By applying the decision tree, substances could be classified into different groups, each characterized by a different probability to induce genotoxic effects. Although none of the investigated substances could be unequivocally identified as genotoxic, the presence of genotoxic effects could neither be excluded for any of them. Consequently, all substances require more data to investigate the genotoxic potential. However, the type and the urge for these data differs among the substances. (C) 2016 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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