Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer
| Autor: | Antonia Anogeianaki, Christos Golias, Dimitrios Peschos, Anastasios Macheras, Anestis Charalampopoulos, Alexander Charalabopoulos, Anna Batistatou, Iosif Iliadis, Konstantinos Charalabopoulos |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Calcitriol Calcitriol/*blood Colorectal cancer chemistry.chemical_element Rectum Calcium Severity of Illness Index General Biochemistry Genetics and Molecular Biology Blood serum Internal medicine Parathyroid Hormone/*blood Vitamin D and neurology Medicine Humans Aged Calcifediol Aged 80 and over Hematology business.industry Calcifediol/*blood Cancer General Medicine Middle Aged medicine.disease medicine.anatomical_structure Endocrinology chemistry Parathyroid Hormone Colorectal Neoplasms/*pathology Female business Colorectal Neoplasms medicine.drug |
| Zdroj: | Clinical and experimental medicine. 10(1) |
| ISSN: | 1591-9528 |
| Popis: | Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing their different levels in serum with healthy individuals. Group 1 (cancer patients) was consisted of 140 patients with CRC with clinical stages Duke's A: 12, B: 52, C: 62, and D: 14. Serum levels of 25(OH)D(3), 1,25(OH)(2)D(3), and PTH were determined in all patients. The findings are: (a) No significant difference was found in the serum levels of 25(OH)D(3) in each Duke's clinical stage in cancer patients, (b) serum 1,25(OH)(2)D(3) levels decreased with advanced cancer stages, and (c) serum levels of PTH showed a corresponding increase. Low serum levels of 1,25(OH)(2)D(3) on one hand and increased levels of PTH in patients with CRC on the other might be strongly related to the carcinogenetic process. Clin Exp Med |
| Databáze: | OpenAIRE |
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