Neural responses to maternal praise and criticism: Relationship to depression and anxiety symptoms in high-risk adolescent girls

Autor: Namik Kirlic, Jennifer Byrd-Craven, Ruben P. Alvarez, Michael M. Criss, Jennifer S. Silk, Raquel Phillips, Matt R. Judah, Robin L. Aupperle, Sally G. Eagleton, Amanda Sheffield Morris
Rok vydání: 2016
Předmět:
Feedback
Psychological
DNA Mutational Analysis
Anxiety
Oxytocin
Prefrontal cortex
Functional Laterality
lcsh:RC346-429
0302 clinical medicine
Image Processing
Computer-Assisted
Praise
Child
Depression (differential diagnoses)
media_common
Brain Mapping
Depression
Parent-child relations
Social perception
05 social sciences
Regular Article
Amygdala
Magnetic Resonance Imaging
Mother-Child Relations
medicine.anatomical_structure
Social Perception
Neurology
Receptors
Oxytocin
lcsh:R858-859.7
Female
medicine.symptom
Psychology
medicine.drug
medicine.medical_specialty
Adolescent
Cognitive Neuroscience
media_common.quotation_subject
lcsh:Computer applications to medicine. Medical informatics
Polymorphism
Single Nucleotide
050105 experimental psychology
03 medical and health sciences
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Maternal behavior
Saliva
Psychiatry
lcsh:Neurology. Diseases of the nervous system
Psychiatric Status Rating Scales
Oxytocin receptor
Oxygen
Self Report
Neurology (clinical)
Photic Stimulation
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 11, Iss C, Pp 548-554 (2016)
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2016.03.009
Popis: Background The parent-child relationship may be an important factor in the development of adolescent depressive and anxious symptoms. In adults, depressive symptoms relate to increased amygdala and attenuated prefrontal activation to maternal criticism. The current pilot study examined how depressive and anxiety symptoms in a high-risk adolescent population relate to neural responses to maternal feedback. Given previous research relating oxytocin to maternal behavior, we conducted exploratory analyses using oxytocin receptor (OXTR) genotype. Methods Eighteen females (ages 12–16) listened to maternal praise, neutral, and critical statements during functional magnetic resonance imaging. Participants completed the Mood and Feelings Questionnaire and the Screen for Child Anxiety Related Emotional Disorders. The OXTR single nucleotide polymorphism, rs53576, was genotyped. Linear mixed models were used to identify symptom or allele (GG, AA/AG) by condition (critical, neutral, praise) interaction effects on brain activation. Results Greater symptoms related to greater right amygdala activation for criticism and reduced activation to praise. For left amygdala, greater symptoms related to reduced activation to both conditions. Anxiety symptoms related to differences in superior medial PFC activation patterns. Parental OXTR AA/AG allele related to reduced activation to criticism and greater activation to praise within the right amygdala. Conclusions Results support a relationship between anxiety and depressive symptoms and prefrontal-amygdala responses to maternal feedback. The lateralization of amygdala findings suggests separate neural targets for interventions reducing reactivity to negative feedback or increasing salience of positive feedback. Exploratory analyses suggest that parents' OXTR genetic profile influences parent-child interactions and related adolescent brain responses.
Highlights • Adolescent brain responses to maternal praise and criticism were examined. • Anxiety related to prefrontal-amygdala response to both criticism and praise. • Exploratory results support a role for the OXTR gene in parent-child interactions.
Databáze: OpenAIRE
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