Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates
| Autor: | Florence Mézenge, Renaud La Joie, Francis Eustache, Justine Mutlu, Louisa Barré, Audrey Perrotin, Denis Guilloteau, Stéphanie Egret, Gaël Chételat, Vincent de la Sayette |
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| Přispěvatelé: | Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), The study was supported by Fondation Plan Alzheimer (Alzheimer Plan 2008-2012), Programme Hospitalier de Recherche Clinique (PHRCN 2011- A01493-38 and PHRCN 2012 12-006-0347), Agence Nationale de la Recherche (LONGVIE 2007), Région Basse-Normandie, Association France Alzheimer et maladies apparentées AAP 2013., Eustache, Francis, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-École Pratique des Hautes Études (EPHE) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Florbetapir-PET Epidemiology Disease Neuropsychological Tests Anxiety Hippocampus 0302 clinical medicine Surveys and Questionnaires Cognitive decline Subclinical infection Depression Health Policy Cognition Alzheimer's disease Magnetic Resonance Imaging Preclinical Cognitive test Psychiatry and Mental health Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Independent Living medicine.symptom Psychology Clinical psychology MRI medicine.medical_specialty 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience Neuroimaging medicine Humans Cognitive Dysfunction [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychiatry Aged 030214 geriatrics Mood Disorders Memory clinic Amyloid β Positron-Emission Tomography Subjective cognitive decline Self Report Neurology (clinical) Geriatrics and Gerontology Atrophy Biomarkers 030217 neurology & neurosurgery Cognitive complaint |
| Zdroj: | Alzheimer's and Dementia Alzheimer's and Dementia, 2017, 13 (5), pp.550-560. ⟨10.1016/j.jalz.2016.08.011⟩ Alzheimer's and Dementia, Elsevier, 2017, 13 (5), pp.550-560. ⟨10.1016/j.jalz.2016.08.011⟩ Alzheimer's & Dementia : the Journal of the Alzheimer's Association Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, 13 (5), pp.550-560. ⟨10.1016/j.jalz.2016.08.011⟩ |
| ISSN: | 1552-5260 1552-5279 |
| Popis: | Introduction Subjective cognitive decline (SCD) could indicate preclinical Alzheimer's disease, but the existing literature is confounded by heterogeneous approaches to studying SCD. We assessed the differential cognitive, affective, and neuroimaging correlates of two aspects of SCD: reporting high cognitive difficulties on a self-rated questionnaire versus consulting at a memory clinic. Methods We compared 28 patients from a memory clinic with isolated SCD, 35 community-recruited elders with similarly high levels of self-reported cognitive difficulties, and 35 community-recruited controls with low self-reported cognitive difficulties. Results Increased anxiety and amyloid β deposition were observed in both groups with high self-reported difficulties, whereas subclinical depression and (hippocampal) atrophy were specifically associated with medical help seeking. Cognitive tests showed no group differences. Discussion These results further validate the concept of SCD in both community- and clinic-based groups. Yet, recruitment methods influence associated biomarkers and affective symptomatology, highlighting the heterogeneous nature of SCD depending on study characteristics. |
| Databáze: | OpenAIRE |
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