Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis
| Autor: | Youngjoong Kwon, Ki Hyun Hong, Young-Min Kim, Soo-Chang Song, Jun Kim, Sungeun Kim, Hae-Ryong Song, Bo-Bae Seo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Triamcinolone acetonide QH301-705.5 media_common.quotation_subject Biomedical Engineering Nanoparticle Osteoarthritis Pharmacology Article Biomaterials Oral administration medicine Synovial fluid Biology (General) Materials of engineering and construction. Mechanics of materials media_common Aqueous solution Chemistry Cartilage Thermosensitive hydrogel medicine.disease medicine.anatomical_structure TA401-492 Polymer nanoparticle Biotechnology medicine.drug Sustained release |
| Zdroj: | Bioactive Materials Bioactive Materials, Vol 7, Iss, Pp 14-25 (2022) |
| ISSN: | 2452-199X |
| Popis: | Treatment of osteoarthritis (OA) by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory medicine. Oral administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration, but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the body. In this study, we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic advantages. Amphiphilic poly(organophosphazene), which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution, was synthesized for triamcinolone acetonide (TCA) delivery. Because hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA, the TCA was encapsulated into the self-assembled polymeric nanoparticles. The TCA-encapsulated polymeric nanoparticles (TePNs) were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular region. However, the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body temperature. An in vitro TCA release study showed sustained TCA release for six weeks. One-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA progression. The OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms. Graphical abstract Image 1 Highlights • An injectable polymeric nanoparticle-based hydrogel loaded with TCA was developed to treat OA. • Nanoparticles via complexation of TCA/polymer were turned into hydrogel after injection and released TCA for a long time. • One-time injection of the hydrogel system showed a great inhibition effect against OA progression and cartilage regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|