Idiopathic Pulmonary Fibrosis in Patients with Early-stage Non-small-cell Lung Cancer after Surgical Resection
| Autor: | Kern Izidor, Pozek Igor, Hribernik Nezka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Lung Neoplasms Exacerbation medicine.medical_treatment Slovenia R895-920 surgery Idiopathic pulmonary fibrosis Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Usual interstitial pneumonia Carcinoma Non-Small-Cell Lung radioterapija Stage (cooking) early-stage non-small-cell lung cancer Aged 80 and over Smokers nedrobnocelični rak pljuč respiratory system kirurgija idiopathic pulmonary fibrosis humanities Tumor Burden medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis zgodnji rak Carcinoma Squamous Cell Female Radiology early-stage cancer Research Article medicine.medical_specialty idiopatska pljučna fibroza Adenocarcinoma 03 medical and health sciences medicine Humans Radiology Nuclear Medicine and imaging Lung cancer udc:616.2 acute exacerbation radiotherapy Aged Retrospective Studies Lung business.industry Retrospective cohort study Non-Smokers medicine.disease respiratory tract diseases Radiation therapy 030228 respiratory system non-small-cell lung cancer business Ex-Smokers |
| Zdroj: | Radiology and Oncology Radiology and Oncology, Vol 53, Iss 3, Pp 357-361 (2019) Radiology and oncology, vol. 53, no. 3, pp. 357-361, 2019. |
| ISSN: | 1581-3207 1318-2099 |
| Popis: | Background The outcomes of patients with both lung cancer and idiopathic pulmonary fibrosis (IPF) are unfavorable. Therapeutic interventions for lung cancer such as surgery can cause acute exacerbation of IPF (aeIPF). This study aimed to assess the frequency of IPF in a group of patients with early-stage non-small-cell lung cancer (NSCLC) and to report clinical characteristics and outcomes of this cohort of patients. Patients and methods This observational cohort retrospective study analyzed 641 pathological records of patients after surgical resection of early-stage non-small-cell lung cancer (NSCLC) at University Clinic Golnik from May 2010 to April 2017. Pathological records of NSCLC with coexisting IPF were reviewed. CT scans and biopsy specimens for this group of patients were analyzed by a thoracic radiologist and pathologist, independently. We searched radiological and pathological features of usual interstitial pneumonia (UIP) pattern in this group of patients. We report the clinical characteristics and outcome of this cohort of patients. Results Out of 641 patients with early-stage NSCLC, only 13 (2.0%) had histologically and radiologically proven coexisting UIP/IPF. Squamous cell carcinoma was the most common type of lung cancer (7/13 patients). The majority of tumors were small size (all being pT1 or pT2), stage I–II (11/13 patients), located in the lower lung lobes (11/13 patients). Almost all patients were current or ex-smokers (11/13 patients). There were two pathologically confirmed fatal cases (15.4%) due to aeIPF in the first two months after radical treatment, one after adjuvant radiotherapy and the other after surgery. Out of 13 patients, one patient had a lung cancer relapse. Conclusions Frequency of UIP/IPF in surgically treated early stage NSCLC is rather low. Our observational study shows that radical treatment of lung cancer can cause aeIPF with dismal outcome in this group of patients. The standard of care in these mostly elderly patients still remains unresolved. |
| Databáze: | OpenAIRE |
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