Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance

Autor:	Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Rok vydání:	2022
Předmět:	Male Organic Chemistry Prostate General Medicine Catalysis Computer Science Applications Inorganic Chemistry Prostatic Neoplasms Castration-Resistant Receptors Androgen Drug Resistance Neoplasm Androgens Humans Physical and Theoretical Chemistry Molecular Biology Spectroscopy
Zdroj:	International journal of molecular sciences. 23(21)
ISSN:	1422-0067
Popis:	All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8bd279f1eb630834a126c72083dec1 https://pubmed.ncbi.nlm.nih.gov/36362304 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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