Key Immunological Functions Involved in the Progression of Epithelial Ovarian Serous Carcinoma Discovered by the Gene Ontology-Based Immunofunctionome Analysis

Autor: Kuo-Min Su, Peng-Hui Wang, Mong Lien Wang, Chi-Kang Lin, Mu-Hsien Yu, Hsin-Yang Li, Cheng-Chang Chang, Kai-Hsi Lu, Cheng-Kuo Lin, Chia Ming Chang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
endocrine system
endocrine system diseases
Serous carcinoma
Megakaryocyte differentiation
Leukocyte mediated immunity
Biology
Carcinoma
Ovarian Epithelial
Catalysis
Article
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
gene set
Ovarian carcinoma
medicine
Humans
030212 general & internal medicine
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Ovarian Neoplasms
immunological function
Organic Chemistry
General Medicine
Antigen receptor-mediated signaling pathway
medicine.disease
female genital diseases and pregnancy complications
Computer Science Applications
Gene Expression Regulation
Neoplastic
ovarian carcinoma
machine learning
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Case-Control Studies
Cancer research
gene expression microarray
Female
Mononuclear cell migration
Cellular extravasation
Leukocyte chemotaxis
integrative analysis
Zdroj: International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3311 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19113311
Popis: Serous carcinoma (SC) is the most common and lethal subtype of epithelial ovarian carcinoma
immunotherapy is a potential treatment for SC, however, the global immunological functions of SC as well as their change during the progression of SC have not been investigated in detail till now. We conducted a genome-wide integrative analysis to investigate the immunofunctionomes of SC at four tumor stages by quantifying the immunological functions defined by the Gene Ontology gene sets. DNA microarray gene expression profiles of 1100 SCs and 136 normal ovarian tissue controls were downloaded from the Gene Expression Omnibus database and converted to the functionome. Then the immunofunctionomes were reconstructed by extracting the offspring from the functionome for the four SC staging groups. The key immunological functions extracted from immunofunctionomes with a series of filters revealed that the immunopathy of SC consisted of a group of deregulated functions with the core members including B cell activation and differentiation, regulation of leukocyte chemotaxis/cellular extravasation, antigen receptor mediated signaling pathway, T helper mediated immunity and macrophage activation
and the auxiliary elements included leukocyte mediated immunity, regulation of inflammatory response, T cell differentiation, mononuclear cell migration, megakaryocyte differentiation, complement activation and cytokine production. These deregulated immunological functions reveal the candidates to target in the immunotherapy.
Databáze: OpenAIRE
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