Primary cutaneous B-cell lymphoma other than marginal zone: clinicopathologic analysis of 161 cases: Comparison with current classification and definition of prognostic markers
| Autor: | Emilio Berti, Aldo Maffi, Pier Luigi Zinzani, Elena Dallera, G. Fraternali-Orcioni, Sara Rattotti, Marco Lucioni, Silvia Franceschetti, Maria Giuseppina Cabras, Francesco Onida, Roberta Riboni, Serena Rupoli, Marco Paulli, Pietro Quaglino, Mariarosa Arra, Marco Santucci, Marcello Gambacorta, Maria Teresa Fierro, Nicola Zerbinati, Giorgio Alberto Croci, Nicola Pimpinelli, Antonio Ramponi, Mauro Alaibac, Luca Arcaini, Carlo Tomasini, Catherine Klersy, Stefano Ascani, Vieri Grandi, Gaia Goteri |
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| Přispěvatelé: | Lucioni, Marco, Berti, Emilio, Arcaini, Luca, Croci, Giorgio A., Maffi, Aldo, Klersy, Catherine, Goteri, Gaia, Tomasini, Carlo, Quaglino, Pietro, Riboni, Roberta, Arra, Mariarosa, Dallera, Elena, Grandi, Vieri, Alaibac, Mauro, Ramponi, Antonio, Rattotti, Sara, Cabras, Maria Giuseppina, Franceschetti, Silvia, Fraternali Orcioni, Giulio, Zerbinati, Nicola, Onida, Francesco, Ascani, Stefano, Fierro, Maria Teresa, Rupoli, Serena, Gambacorta, Marcello, Zinzani, PIER LUIGI, Pimpinelli, Nicola, Santucci, Marco, Paulli, Marco |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology Cancer Research Skin Neoplasms BCL2 Cutaneous lymphoma Follicular lymphoma Large cell lymphoma Leg type Oncology Radiology Nuclear Medicine and Imaging cutaneous lymphoma follicular lymphoma large cell lymphoma leg type Adult Aged Aged 80 and over Biomarkers Tumor Diagnosis Differential Female Humans Interferon Regulatory Factors Lymphoma B-Cell Middle Aged Neprilysin Prognosis Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-myc Retrospective Studies Survival Analysis 030207 dermatology & venereal diseases 0302 clinical medicine Nuclear Medicine and Imaging hemic and lymphatic diseases Centroblasts Original Research Not Otherwise Specified Large-cell lymphoma BCL6 Marginal zone 030220 oncology & carcinogenesis Radiology medicine.medical_specialty 03 medical and health sciences medicine Radiology Nuclear Medicine and imaging business.industry Clinical Cancer Research medicine.disease Lymphoma business |
| Zdroj: | Cancer Medicine |
| Popis: | Categorization of primary cutaneous B‐cell lymphomas (PCBCL) other than marginal zone (MZL) represents a diagnostic challenge with relevant prognostic implications. The 2008 WHO lymphoma classification recognizes only primary cutaneous follicular center cell lymphoma (PCFCCL) and primary cutaneous diffuse large B‐cell lymphoma, leg type (PCDLBCL‐LT), whereas the previous 2005 WHO/EORTC classification also included an intermediate form, namely PCDLBCL, other. We conducted a retrospective, multicentric, consensus‐based revision of the clinicopathologic characteristics of 161 cases of PCBCL other than MZL. Upon the histologic features that are listed in the WHO classification, 96 cases were classified as PCFCCL and 25 as PCDLBCL‐LT; 40 further cases did not fit in the former subgroups in terms of cytology and/or architecture, thus were classified as PCDLBCL, not otherwise specified (PCDLBCL‐NOS). We assigned all the cases a histogenetic profile, based on the immunohistochemical detection of CD10, BCL6, and MUM1, and a “double hit score” upon positivity for BCL2 and MYC. PCDLBCL‐NOS had a clinical presentation more similar to PCFCCL, whereas the histology was more consistent with the picture of a diffuse large B‐cell lymphoma, as predominantly composed of centroblasts but with intermixed a reactive infiltrate of small lymphocytes. Its behavior was intermediate between the other two forms, particularly when considering only cases with a “non‐germinal B‐cell” profile, whereas “germinal center” cases resembled PCFCCL. Our data confirmed the aggressive behavior of PCDLBC‐LT, which often coexpressed MYC and BCL2. The impact of single factors on 5‐year survival was documented, particularly histogenetic profile in PCDLBCL and BCL2 translocation in PCFCCL. Our study confirms that a further group—PCDLBCL‐NOS—exists, which can be recognized through a careful combination of histopathologic criteria coupled with adequate clinical information. |
| Databáze: | OpenAIRE |
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