Hepatic tumours during androgen therapy in Fanconi anaemia
| Autor: | R. L. Touraine, P. Foray, N. Philippe, Yves Bertrand, J. Gilly |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adenoma
Male Oncology medicine.medical_specialty Bone marrow transplantation medicine.drug_class medicine.medical_treatment Norethandrolone Fanconi anemia Internal medicine medicine Humans Hepatic tumours Child Chemotherapy business.industry Liver Neoplasms medicine.disease Androgen Haematopoiesis Fanconi Anemia Endocrinology Androgen Therapy Pediatrics Perinatology and Child Health Toxicity business |
| Zdroj: | European Journal of Pediatrics. 152:691-693 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/bf01955250 |
| Popis: | The occurrence of liver tumours in the course of Fanconi anaemia (FA) has been well documented. We present a case, review the literature and conclude that androgen therapy would increase the risk of developing tumours, most of which appear to be benign (adenomas or peliosis) and androgen-dependent, generally decreasing in size after cessation of treatment. Survival of patients is poor, mostly because of the rapid evolution of untreated FA, rather than rupture or degencration of the tumour. In the absence of an allogenic bone marrow transplantation, administration of haematopoietic growth factors might be effective. As a preventive measure, other types of unsubstituted androgens may be used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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