Dopaminergic responses in the core part of the nucleus accumbens to subcutaneous MK801 administration are increased following postnatal transient blockade of the prefrontal cortex

Autor: Francisca Meyer, Emmanuelle Tagliabue, Tiphaine Pouvreau, Alain Louilot, Séverine Eybrard
Přispěvatelé: Faculty of Medicine-ULP
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Dopamine
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Dopamine Agents
Prefrontal Cortex
Striatum
Tetrodotoxin
Nucleus accumbens
Receptors
N-Methyl-D-Aspartate
Nucleus Accumbens
Rats
Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
medicine
Animals
Prefrontal cortex
ComputingMilieux_MISCELLANEOUS
Dopaminergic
Ventral striatum
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Corpus Striatum
030227 psychiatry
Rats
Dizocilpine
Neostriatum
Disease Models
Animal
medicine.anatomical_structure
Animals
Newborn
Schizophrenia
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
NMDA receptor
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Dizocilpine Maleate
Psychology
Neuroscience
030217 neurology & neurosurgery
Locomotion
medicine.drug
Zdroj: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2017, 335, pp.191-198. ⟨10.1016/j.bbr.2017.08.021⟩
ISSN: 0166-4328
1872-7549
DOI: 10.1016/j.bbr.2017.08.021⟩
Popis: Schizophrenia is a complex and devastating neuropsychiatric disease thought to result from impaired connectivity between several integrative regions, stemming from developmental failures. In particular, the left prefrontal cortex of schizophrenia patients seems to be targeted by such early developmental disturbances. Data obtained over the last three decades support the hypothesis of a dopaminergic dysfunction in schizophrenia. Striatal dopaminergic dysregulation in schizophrenia may result from a dysconnection between the prefrontal cortex and the striatum (dorsal and ventral) involving glutamatergic N-methyl-d-aspartate (NMDA) receptors. In the context of animal modeling of the pathophysiology of schizophrenia, the present study was designed to investigate the effects of MK 801 (dizocilpine) on locomotor activity and dopaminergic responses in the left core part of the nucleus accumbens (ventral striatum) in adult rats following neonatal tetrodotoxin inactivation of the left prefrontal cortex (infralimbic/prelimbic region) at postnatal day 8. Dopaminergic variations were recorded in the nucleus accumbens by means of in vivo voltammetry in freely moving adult animals. Following MK 801 administration, and in comparison to control (PBS) animals, animals microinjected with tetrodotoxin display locomotor hyperactivity and increased extracellular dopamine levels in the core part of the nucleus accumbens. These findings suggest neonatal functional inactivation of the prefrontal cortex may lead to a dysregulation of dopamine release in the core part of the nucleus accumbens involving NMDA receptors. The results obtained may provide new insight into the involvement of NMDA receptors in the pathophysiology of schizophrenia and suggest that future studies should look carefully at the core of the nucleus accumbens.
Databáze: OpenAIRE
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