Treating symptoms and reversing remodelling: clinical and echocardiographic 1-year outcomes with percutaneous mitral annuloplasty for mild to moderate secondary mitral regurgitation
| Autor: | Tomasz Siminiak, Janusz Lipiecki, Ralph Stephan von Bardeleben, Horst Sievert, Wayne C. Levy, Randall C. Starling, David M. Kaye, Steven L. Goldberg, Klaus K Witte |
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| Rok vydání: | 2021 |
| Předmět: |
Heart Failure
medicine.medical_specialty Mitral regurgitation Ejection fraction Vena contracta Percutaneous New York Heart Association Class Mitral Valve Annuloplasty business.industry Mitral Valve Insufficiency medicine.disease Confidence interval Treatment Outcome Quality of life Echocardiography Internal medicine Heart failure medicine Cardiology Quality of Life Humans Cardiology and Cardiovascular Medicine business |
| Zdroj: | European journal of heart failureReferences. 23(11) |
| ISSN: | 1879-0844 |
| Popis: | Aims- To determine the effects of percutaneous mitral annuloplasty on symptoms, walk distance and left ventricular (LV) structure and function in patients with mild or moderate secondary mitral regurgitation (SMR). Methods and results- This was a pooled analysis of patients (n = 68) who, despite guideline-directed medical therapy had symptomatic heart failure (HF) with mild (n = 25) or moderate (n = 43) SMR treated with percutaneous mitral annuloplasty as part of the TITAN, TITAN II, or REDUCE-FMR trials. Primary outcomes were changes in symptoms, 6-min walk distance, and quality of life assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ) after 1 year. Secondary analyses included changes in LV structure and function. At 1 year, New York Heart Association class status was maintained (48%) or improved (46%) in most patients, mean KCCQ scores increased from baseline by 10 units [95% confidence interval (CI) 3 to17; P |
| Databáze: | OpenAIRE |
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