A train of electrical pulses applied to the primary auditory cortex evokes a conditioned response in guinea pigs
| Autor: | Yuji Okuda, Wen Jie Song, Hiroshi Shikata |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Auditory Pathways Time Factors genetic structures Guinea Pigs Neural Conduction Stimulation Audiology Auditory cortex Extinction Psychological Cortex (anatomy) Auditory prosthesis medicine Reaction Time Animals Auditory Cortex Blinking General Neuroscience Conditioned response Classical conditioning Electrical shock Auditory Threshold General Medicine Extinction (psychology) Conditioning Eyelid Electric Stimulation medicine.anatomical_structure Acoustic Stimulation Auditory Perception Feasibility Studies Psychology Neuroscience |
| Zdroj: | Neuroscience research. 71(1) |
| ISSN: | 1872-8111 |
| Popis: | As a step to develop auditory prosthesis by cortical stimulation, we tested whether a single train of pulses applied to the primary auditory cortex could elicit classically conditioned behavior in guinea pigs. Animals were trained using a tone as the conditioned stimulus and an electrical shock to the right eyelid as the unconditioned stimulus. After conditioning, a train of 11 pulses applied to the left AI induced the conditioned eye-blink response. Cortical stimulation induced no response after extinction. Our results support the feasibility of auditory prosthesis by electrical stimulation of the cortex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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