Serum lactate dehydrogenase is a predictive biomarker in patients with oropharyngeal cancer undergoing radiotherapy: Retrospective study on predictive factors
| Autor: | Y. Oguma, Hisato Kawakami, Hiroshi Doi, Yutaro Wada, Makoto Hosono, Saori Tatsuno, Kiyoshi Nakamatsu, Kazuki Ishikawa, Takuya Uehara, Masahiro Inada, Yasumasa Nishimura |
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| Rok vydání: | 2021 |
| Předmět: |
serum lactate dehydrogenase
Male medicine.medical_specialty Multivariate analysis oropharyngeal cancer medicine.medical_treatment head and neck squamous cell carcinoma Gastroenterology Internal medicine medicine Humans Stage (cooking) human papillomavirus Lactate Dehydrogenases radiotherapy Neoplasm Staging Retrospective Studies Univariate analysis Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Albumin Cancer Retrospective cohort study Original Articles Prognosis medicine.disease Head and neck squamous-cell carcinoma Radiation therapy Oropharyngeal Neoplasms Otorhinolaryngology Head and Neck Neoplasms Original Article business Biomarkers |
| Zdroj: | Head & Neck |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.26814 |
| Popis: | Background The present study aimed to evaluate the prognostic factors in human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal cancer (OPC) treated with definitive radiotherapy. Methods We retrospectively evaluated 101 patients with OPC who underwent definitive radiotherapy between 2008 and 2018. Results The median follow‐up period of the surviving patients was 68 months (range, 8–164 months). The 5‐year overall survival rate was 69.8%. Univariate analyses revealed that poor survival was associated with male sex, smoking ≥30 pack‐years, Eastern Cooperative Oncology Group performance status ≥1, tumor‐node‐metastasis (TNM) stage III‐IV (8th edition), HPV‐negativity, serum lactate dehydrogenase (LDH) ≥202, C‐reactive protein/albumin ratio ≥0.15, and lymphocyte‐to‐monocyte ratio |
| Databáze: | OpenAIRE |
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